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Accredited Drug Testing provides extensive drug and alcohol testing services at our 33 testing sites in East Point, Alabama. We're equipped with DOT and non-DOT urine drug tests, breath alcohol analyzes, EtG alcohol screenings, and hair drug tests for personal, business, and legal purposes. In East Point, AL, we offer quick results and SAMSA-approved laboratory evaluations. Most tests are conveniently located a short distance from your workplace or residence, with same-day services available. We also perform Occupational Health Testing, Clinical Assessments, and conduct Background Checks.
To schedule, dial (800) 221-4291 or sign up online. Pick the required test and your preferred testing center location. Testing services are available for you, your staff, or another party. Call anytime or book online to arrange a test effortlessly—our simple process ensures easy drug testing arrangements near East Point.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our East Point drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
In East Point, AL, employers often implement drug testing policies as part of their hiring and workplace safety procedures. These policies are designed to ensure a drug-free environment, which can help improve productivity and reduce workplace accidents. Many employers comply with state regulations that provide guidelines for conducting fair and consistent drug tests. To learn more about Alabama's guidelines, visit the Alabama State Government website.
Companies in East Point may conduct various types of drug tests, including pre-employment, random, and post-accident tests. Pre-employment screening is commonly used to filter candidates who may pose risks due to substance abuse. Meanwhile, random testing serves as a deterrent and encourages ongoing compliance among employees. For federal guidelines, employers often refer to the U.S. Department of Labor site.
Although drug testing can play a crucial role in workplace safety, employers in East Point must also balance these policies with employees’ rights to privacy. Transparency regarding drug testing procedures is critical to maintain trust within the workforce. Employers should provide clear information on the types of tests conducted and the substances screened. For more on employees' rights, the U.S. Equal Employment Opportunity Commission offers valuable resources.
In East Point, AL, local initiatives are actively addressing drug issues through collaboration with law enforcement and community outreach. The city's approach includes educational programs, aiming to increase awareness about the dangers of drug abuse. For more on local efforts, visit the East Point City Government website.
Such local initiatives are supported by state resources provided by the Alabama Department of Public Health, which offers treatment and prevention programs to combat substance abuse. Additionally, federal support is facilitated through the efforts of the Substance Abuse and Mental Health Services Administration (SAMHSA). These agencies work together to provide a comprehensive strategy to mitigate drug problems in the area.
In recent months, East Point, AL, has seen a significant increase in local drug busts, with law enforcement stepping up efforts to combat the illicit drug trade. Authorities have noted a rise in the distribution of opioids and methamphetamine, prompting coordinated operations to curb the flow of these substances. Increased community awareness and tips have played a crucial role in the success of these crackdowns.
The East Point Police Department recently reported dismantling a local drug ring that had been operating covertly for over a year. The operation led to multiple arrests and the seizure of large quantities of illegal substances, along with weapons and cash. Officials emphasized the importance of ongoing community vigilance and cooperation in continuing to prevent drug-related activity in the area.
In an effort to educate the public and provide support, East Point has also launched community outreach programs focused on drug prevention and rehabilitation. Local organizations are working alongside law enforcement to provide resources and education to those struggling with addiction. These initiatives aim to not only treat and rehabilitate but also prevent future involvement in drug-related activities.
The impact of these efforts can be seen in the community's increasing engagement with local law enforcement. Residents have become more proactive in reporting suspicious activities, greatly assisting police in their operations. As trust between the community and authorities grows, there is optimism in East Point about reducing the prevalence of drug-related issues and improving overall safety and wellbeing.
Accredited Drug Testing offers fast, reliable employment screening services in East Point, AL. Trusted by employers nationwide for accurate results and exceptional service.
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024