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Our 34 testing centers in the Hollis Crossroads, Alabama region deliver extensive drug and alcohol testing solutions. We cater to DOT and non-DOT urine analyses, breath alcohol evaluations, EtG alcohol screenings, plus hair drug tests for personal, corporate, and legal purposes. Quick results are offered locally with SAMSA certified lab processing, usually accessible near your house or workplace. Same day services, along with Occupational Health Evaluation, Clinical Analysis, and Background Review, are also available.
Dial (800) 221-4291 or go online to book. Pick your test and the closest site for yourself or someone else. It's fast and simple—call our team or set it up any time online. Our efficient, straightforward system makes arranging a drug test near Hollis Crossroads hassle-free.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Hollis Crossroads drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Hollis Crossroads, Randolph County, an estimated 7% of the population reported misuse of prescription drugs in the past year.
Randolph County saw a 12% increase in opioid-related hospital visits over the past two years.
In a recent survey, 15% of high school students in Hollis Crossroads reported experimenting with illicit drugs.
The number of drug-related arrests in Hollis Crossroads has risen by 8% in the last year.
Substance abuse disorder affects approximately 6% of Hollis Crossroads residents, according to a county health report.
Randolph County saw a 5% uptick in substance abuse treatment admissions, reflecting efforts in Hollis Crossroads.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Hollis Crossroads prioritize maintaining a drug-free environment through stringent testing policies. These include pre-employment testing and random drug screenings. Such practices comply with guidelines established by the U.S. Department of Labor.
Recognizing the impact of drug use in the workplace, businesses collaborate with local health services to offer assistance and resources to employees impacted by substance abuse. Employers actively engage in programs to educate employees about drug misuse and its consequences.
The government of Hollis Crossroads, in collaboration with Randolph County, has initiated several strategies to combat drug abuse. These include public awareness campaigns and support for local rehabilitation programs. More details can be found on the Alabama Department of Public Health website.
Additionally, the county participates in state-sponsored initiatives to reduce opioid addiction, leveraging resources from the Substance Abuse and Mental Health Services Administration. These efforts address prevention and recovery at both the community and individual levels.
Law enforcement in Hollis Crossroads recently conducted a series of drug busts, seizing significant quantities of illegal substances. These efforts are part of ongoing operations facilitated by the Randolph County Sheriff's Office to curb drug trafficking in the area.
Community involvement has been paramount, with residents cooperating with authorities to identify and dismantle drug distribution networks. Such initiatives highlight the importance of collaboration between law enforcement and citizens to tackle drug-related crime.
Drug awareness events and educational workshops are periodically held to inform the public about the risks associated with drug use and to promote available treatment resources. These gatherings aim to strengthen community resilience against the toll of substance abuse.
Accredited Drug Testing offers fast, reliable employment screening services in Hollis Crossroads, AL. Trusted by employers nationwide for accurate results and exceptional service.
Alabama Department of Mental Health
Bradford Health Services - Oxford
East Alabama Mental Health Center
Alabama Department of Public Health
SAMHSA
Unite, Inc.
East Alabama Workforce Development
Alabama Pain Physicians
AltaPointe Health
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024