Drug Testing Locations - Westover, AL

Drug Testing in Westover, AL

Westover, Alabama Statistics

In 2022, Shelby County, where Westover is located, reported a 5% increase in opioid overdose cases.

A 2021 study in Shelby County showed that 12% of high school students in Westover admitted to using drugs.

In 2022, 7% of adults in Westover, Shelby County, reported illicit drug use in the past year.

Shelby County witnessed a 15% rise in drug-related arrests in 2022, impacting areas including Westover.

A 2023 survey highlighted that 25% of Shelby County's ER visits in Westover were related to substance abuse.

Westover, in Shelby County, accounted for 10% of the county's drug rehab admissions in 2021.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Westover, AL & Drug Testing Policies

In Westover, AL, many employers have implemented strict drug testing policies to ensure a safe work environment. Companies often conduct pre-employment screenings and random drug tests, adhering to guidelines set by the Occupational Safety and Health Administration to deter drug misuse.

Larger employers in the area, such as those in manufacturing and logistics, are particularly stringent with their policies. These policies are aligned with federal and state laws, which help maintain compliance and safety standards across industries.

The implementation of drug-free workplace programs, often supported by state resources such as the Alabama Department of Labor, not only protects businesses but also provides employees with access to support services if needed.

Government Efforts with Drug Problems in Westover, AL

The government of Westover, AL, in collaboration with Shelby County Government, has intensified its efforts to address drug abuse. Initiatives include increased funding for local rehabilitation centers and educational programs aimed at prevention and awareness, targeting both youth and adults.

State-level initiatives have also been influential, with the Alabama Department of Mental Health providing resources and programs to support communities like Westover. These coordinated efforts focus on providing treatment options and reducing the stigma associated with addiction.

Local Drug Busts & News in Westover, AL

Westover, AL has witnessed several drug-related events over recent years, emphasizing the ongoing issue of substance abuse in the community. In 2023, a major drug bust in Shelby County, which includes Westover, resulted in the seizure of over $1 million worth of illegal drugs.

This operation, led by the Shelby County Drug Enforcement Task Force, highlighted the cooperation between local and state law enforcement in combating drug trafficking and distribution. Such events showcase the proactive measures being taken to protect the community.

Additionally, community-driven events aimed at raising awareness and providing education on the dangers of drug abuse have been pivotal. These events often involve local law enforcement and public health officials working together to reduce drug-related issues in Westover.

Occupational Health Services

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Resources & Citations

SAMHSA

Alabama Dept. of Mental Health

Shelby County Government

Alabama Dept. of Public Health

Alabama Board of Nursing Addiction Treatment

Children's of Alabama

Addiction & Overdose Prevention Task Force

Alabama School-Based Abstinence Program

Alabama Hands & Voices

Blue Tree Counseling

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