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Accredited Drug Testing provides all-encompassing drug and alcohol testing services in the 1 Pelican, Alaska area centers. We offer both DOT and non-DOT urine tests, along with breath and EtG alcohol assessments, as well as hair drug screenings for personal, professional, and legal purposes. In Pelican, AK, we ensure rapid test results and certified SAMSA laboratory analysis, with same-day service availability, and most testing centers are conveniently located near your residence or workplace. Our additional offerings include Occupational Health Testing, Clinical Testing, and Background Checks.
Dial (800) 221-4291 or register on our website. Easily select a test and pick a convenient location—testing is accessible to individuals, employees, or others. Bookings are quick and straightforward, contact our scheduling unit or schedule online anytime, day or night. Our efficient process facilitates easy arrangement of drug screenings near Pelican.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Pelican drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Pelican, AK, prioritize workplace safety and adhere to stringent drug testing policies. To ensure compliance with local legislation, they often align their practices with guidelines outlined by the Alaska Department of Labor and Workforce Development. For detailed information, visit the Alaska Department of Labor and Workforce Development.
Compliance with federal drug testing regulations is essential for Pelican employers, who must ensure their policies meet standards set by national authorities. The U.S. Department of Transportation provides regulations for companies in the transportation sector, which can be reviewed at the Office of Drug and Alcohol Policy and Compliance.
State-wide initiatives and legal guidelines are critical for employers crafting drug policies in Pelican. For a comprehensive understanding of these policies, businesses can consult resources available through the Alaska State Legislature’s official site at the Alaska State Legislature. Strict adherence ensures a safe and productive work environment.
The government of Pelican, AK, collaborates with local organizations and law enforcement to tackle drug issues. Initiatives focus on prevention, education, and community support. The goal is to reduce substance abuse and provide resources through partnerships with agencies like the Drug Enforcement Administration and local health services.
Efforts at the state level involve collaboration with the Alaska Department of Health and Social Services to implement policies aimed at reducing addiction rates and improving public health through accessible treatment programs. Federal grants help support these initiatives, offering resources for rehabilitation and community outreach programs.
In Pelican, AK, recent law enforcement efforts have focused on curbing the spread of illegal narcotics in the small fishing community. The local police department has carried out multiple drug busts, seizing significant quantities of illicit substances. These operations have been instrumental in reducing drug-related crime and improving public safety, reflecting the commitment of local authorities to combat drug issues.
The community of Pelican has rallied together in support of drug prevention programs after a notable bust exposed an organized drug distribution network. Local organizations have initiated awareness campaigns, engaging residents in educational workshops about the dangers of drug use. These initiatives are critical in fostering a drug-free environment and encouraging young people to make healthier lifestyle choices.
Law enforcement is actively collaborating with state authorities in Pelican, AK, to dismantle drug trafficking operations. Recent joint efforts have resulted in the apprehension of key figures involved in distributing narcotics. These successful partnerships highlight the importance of interagency cooperation in ensuring the safety and well-being of Pelican residents, while also sending a strong message to those attempting to exploit the community.
Following a series of drug-related events, Pelican's local government has increased funding for drug rehabilitation programs. With a focus on recovery and reintegration, these programs aim to help individuals struggling with addiction to find new opportunities and rebuild their lives. This supportive approach is crucial in addressing the root causes of drug abuse and fostering long-term community health.
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This is by far the easiest way to get my lab work ordered and paid for. The phone calls are short and to the point. They don’t try to push extra sales on you and when I walk in to the clinic I simply show my donor pass and with in a matter of minutes I’m done. I will continue to use ADT in the future.
Jason Jackson - 7/19/2025
Everything was great, the staff was very polite. Thank you.
Olga Petrova - 9/19/2024
The visit here is always the best . The place is always really clean. The employees are super courteous, very polite, and professional. This is the only drug lab I like to go do my drug and alcohol test. I would like to tell them thank you so much for thier excellent performance and job
Eli Gonzalez - 1/4/2025