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At our 33 testing facilities throughout the Central Coast in California, Accredited Drug Testing provides a wide range of drug and alcohol screenings. These include DOT and regular urine analysis, breath tests for alcohol, EtG alcohol analysis, and hair drug tests suitable for personal, business, or legal purposes. Our Central Coast locations support rapid testing and are SAMSA certified for lab work, offering fast service, often just minutes away from your office or residence. We also provide additional services like Occupational Health Testing, Clinical Testing, and Background Checks.
Get in touch at (800) 221-4291 or sign up online. Just pick your test type and choose a nearby center—whether it's for yourself, your staff, or another person. Scheduling is quick and uncomplicated; either phone our team or arrange your test online any time. With our efficient and uncomplicated system, organizing drug tests in Central Coast is a straightforward process.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Central Coast drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Santa Cruz County reported a 15% increase in opioid overdose deaths in 2020.
In Monterey County, 23% of high school students admitted to trying marijuana before age 15.
San Luis Obispo County experienced a 32% rise in methamphetamine-related ER visits in 2021.
Watsonville, Santa Cruz County, saw a 40% spike in fentanyl-related incidents in 2022.
Salinas, Monterey County, had over 482 opioid prescriptions per 1,000 residents in 2020.
Paso Robles, San Luis Obispo County, recorded 67 heroin overdoses in 2021.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers across the Central Coast, CA, enforce various drug testing policies aimed at maintaining a drug-free work environment. Many of these policies align with federal guidelines provided by the United States Department of Labor. For comprehensive regulations, you can refer to the U.S. Department of Labor website.
Businesses in Santa Cruz and Paso Robles often conduct pre-employment and random drug tests. Monterey County companies may include it as part of a broader employee health program. Employers in the region adhere to guidelines set by the Department of Labor to ensure legal compliance.
The government in Central Coast, CA is tackling drug issues through various efforts. Santa Cruz County has launched the 'Safe Rx Santa Cruz County' initiative to promote safe storage and disposal of prescription drugs. For more information, you can visit the Healthy Santa Cruz County website.
Monterey County collaborates with the state on the California MAT Expansion Project, increasing access to medication-assisted treatment for opioid addiction. More information is available on the California MAT Expansion website.
Recently, authorities in the Central Coast of California have intensified their efforts to combat drug-related activities. Law enforcement agencies have been conducting a series of raids resulting in significant drug busts. These operations often uncover large quantities of illegal substances such as methamphetamine and fentanyl, highlighting the ongoing struggle against drug trafficking in the area.
One of the notable incidents this year was a coordinated operation that led to the arrest of multiple individuals suspected of being part of a larger drug distribution network. This crackdown aimed to disrupt the flow of narcotics into Central Coast communities, often through sophisticated transportation methods that evade traditional detection.
The impact of these drug busts extends beyond immediate arrests. They forge stronger collaborations between local, state, and federal agencies that are crucial for long-term success. Moreover, these events have fueled community dialogues on prevention strategies, including educational programs aimed at reducing drug abuse among youth.
Resident feedback has underscored the importance of continued vigilance. Locals appreciate the increased police presence, leading to enhanced feelings of safety. However, community leaders emphasize that addressing root causes such as addiction must accompany enforcement to ensure sustainable solutions to the drug issues plaguing the region.
Efforts to curb drug trafficking in the Central Coast are multifaceted, involving surveillance, undercover operations, and public awareness campaigns. As authorities continue their diligent work, they face the challenging task of balancing enforcement with support for rehabilitation services, aiming to reduce the prevalence of addiction and its societal impacts.
Accredited Drug Testing offers fast, reliable employment screening services in Central Coast, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
Santa Cruz Health Services Agency
Monterey County Behavioral Health
San Luis Obispo County Behavioral Health
Pierce Institute for the Study of Drug Policy
California Health Care Foundation
Narconon California
Drug Free Northern California
Get Smart About Drugs
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024