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At Accredited Drug Testing, we provide a full range of drug and alcohol screening services at 37 testing centers across East San Gabriel Valley, CA. Our offerings include DOT and non-DOT urine analyses, breath alcohol evaluations, EtG alcohol tests, and hair follicle screenings suitable for individuals, employers, and legal matters. Rapid test results and certified lab analyses are available in East San Gabriel Valley, with most sites conveniently located nearby. We also provide Occupational Health Testing, Clinical Testing, and Background Checks.
To schedule, call (800) 221-4291 or register online. Select the test, then pick a location nearby—available for individuals or employee groups. Arranging a test is quick and hassle-free via our 24/7 scheduling department or online platform. Our simple process makes drug testing near East San Gabriel Valley convenient and straightforward.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our East San Gabriel Valley drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Pomona, Los Angeles County, opioid-related hospitalizations increased by 15% from 2018 to 2020.
West Covina, in Los Angeles County, reported a 10% rise in cocaine-related arrests compared to the previous year.
The city of Glendora, Los Angeles County, noted a 25% increase in drug treatment program enrollments in 2020.
Drug-related DUI arrests in La Puente, Los Angeles County, saw a 12% hike in 2019.
In Azusa, Los Angeles County, methamphetamine confiscations surged by 30% over a three-year period.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in East San Gabriel Valley, CA, recognize the critical role of maintaining a drug-free workplace. Many companies have adopted rigorous drug testing policies as a condition of employment, both pre-employment and randomly after hiring. These policies are often guided by state regulations that prioritize workplace safety.
California state law permits employers to implement drug testing policies, provided they do not infringe on employee rights. For more details on these regulations, the California Department of Industrial Relations offers a comprehensive overview of employer responsibilities and employee rights.
Companies may utilize third-party agencies to conduct drug screenings efficiently and confidentially. These policies align with federal guidelines aimed at reducing substance abuse in the workforce, ensuring consistent productivity and safety standards across industries.
The government has implemented several initiatives to combat drug abuse in the East San Gabriel Valley, CA. Collaborative efforts among city councils aim to enhance educational programs that highlight the dangers of drug use for youth and adults alike. City of Pomona offers resources for drug prevention programs.
Local law enforcement, in partnership with the Los Angeles County government, has increased patrols and surveillance in areas prone to drug-related activities. These efforts are complemented by federal backing through funding and strategic guidance. Visit the Los Angeles County Government website for more information.
In recent months, authorities have intensified efforts to combat the surge in illegal drug activities across the East San Gabriel Valley. Notable operations have led to significant confiscations of fentanyl and methamphetamine, highlighting the region's ongoing battle against narcotics and their distribution networks. Collaborative task forces focus on dismantling these operations, aiming to improve community safety.
One major drug bust occurred when local police, working with federal agencies, executed a raid on a suspected manufacturing facility in Pomona. This operation resulted in the seizure of large quantities of synthetic drugs intended for widespread distribution. The bust not only removed harmful substances from circulation but also provided valuable insights into the operational tactics of these clandestine groups.
The communities within the East San Gabriel Valley have become increasingly active in addressing drug-related issues. Through neighborhood watch programs and public forums, residents are encouraged to report suspicious activities. These initiatives aim to foster a cooperative environment in which law enforcement can more effectively tackle the drug epidemic.
Efforts to curb drug trafficking in the East San Gabriel Valley also extend to public health programs that focus on education and rehabilitation. Local agencies are implementing preventive measures to help reduce the demand for illicit substances. By promoting awareness and providing resources for treatment, the region hopes to combat the root causes of addiction and limit the influence of drug-related crime.
Accredited Drug Testing offers fast, reliable employment screening services in East San Gabriel Valley, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
California Department of Alcohol and Drug Programs
California Alcohol and Drug Program Services
Southern California Governor's Office
Los Angeles Recovery Resources
CA Rehab Services
Council on Alcoholism and Drug Dependencies
SoCal Rehabilitation Center
East SGV Aid and Support
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024