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Accredited Drug Testing is proud to deliver extensive drug and alcohol testing services at our 25 testing sites around Fellows, California. Our offerings include both DOT and non-DOT urine drug assays, breathalyzer alcohol screenings, EtG alcohol detection, and hair follicle testing, catering to personal, employment, and legal requirements. In Fellows, CA, we provide fast result testing as well as SAMSA-endorsed lab evaluations, available the same day. Most Fellows screening centers are conveniently situated near your residence or workplace. We also furnish services like Occupational Health Testing, Clinical Testing, and Background Checks.
Contact us at (800) 221-4291 or via our website to book your test. Choose the desired test, pick a convenient center, and you can arrange for assessments applicable to you, your staff, or third parties. Setting up a test is swift and straightforward. Call our team or use our 24/7 online scheduling system. Our efficient, uncomplicated setup enables seamless drug testing coordination near Fellows.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Fellows drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Kern County, where Fellows is located, there was a 15% increase in drug-related emergency room visits between 2019 and 2021.
Fellows, CA, part of Kern County, reported a rise in opioid prescriptions, increasing by 10% in 2020.
In Kern County, over 800 cases of substance abuse were reported in community health centers in 2020.
Methamphetamine-related arrests in Fellows, CA, accounted for nearly 25% of all drug arrests in Kern County in 2020.
Kern County's health department recorded a 20% increase in youth drug abuse assessments in 2020.
Between 2019-2021, Kern County saw a surge in drug overdose deaths, impacting communities like Fellows, CA, by 30%.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Fellows, CA, recognize the importance of maintaining a drug-free workplace. Many have implemented drug testing policies in line with state regulations. These policies help ensure safety and productivity within their operations.
Organizations often collaborate with agencies such as the California Department of Industrial Relations to align their drug policies with industry standards. This cooperation enhances the overall effectiveness of the policies, helping employees receive the necessary support and guidance.
Mandatory drug testing during the hiring process and random testing ensure compliance. This practice not only deters drug abuse but also aids in the identification of employees who may need assistance, contributing to healthier workplace environments.
The government of Kern County, encompassing Fellows, CA, has been actively addressing the drug issues through education and rehabilitation initiatives. Local efforts include community workshops and partnerships with schools to spread awareness. State and federal support bolsters these efforts to ensure a coordinated response.
For more information, residents can visit the Kern County Behavioral Health & Recovery Services or the Substance Abuse and Mental Health Services Administration. These resources provide guidance on available programs and preventative measures.
Recent efforts in Fellows, CA, have led to significant drug busts, illustrating the community's commitment to combating drug activity. Law enforcement agencies continue to prioritize interventions that disrupt local drug trade networks.
Collaborations between local police and federal agencies, such as the DEA, have yielded positive outcomes. For instance, a notable operation in 2022 saw the seizure of large quantities of illegal substances, reducing their availability in the community.
These events highlight the proactive approach taken by law enforcement officials to address and mitigate drug-related issues, ensuring a safer environment for the residents of Fellows, CA.
Accredited Drug Testing offers fast, reliable employment screening services in Fellows, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
Kern County Behavioral Health & Recovery Services
Substance Abuse and Mental Health Services Administration
California Drug Rehabs
California Health and Human Services
CRC Health
CA Recovery Network
California Department of Alcohol and Drug Programs
DeNova Treatment Centers
Addiction Center California
Narcotics Anonymous
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024