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Comprehensive drug and alcohol testing services are available at our 32 testing facilities in the Highland, California region through Accredited Drug Testing. We offer both DOT and non-DOT urine drug screenings, along with breath and EtG alcohol evaluations, and hair follicle drug tests for individuals, businesses, and legal purposes. In Highland, CA, swift testing services and certified lab analyses by SAMSA are available, with same-day services, making most testing venues just minutes from where you reside or work. We also provide Occupational Health Examinations, Clinical Testing, and Background Verification services.
Dial (800) 221-4291 or go online to register. The process is simple: choose your test, find a nearby site, and arrange testing for yourself, an employee, or someone else. Scheduling is quick and straightforward; contact our scheduling team or book your test around the clock online. Our efficient, easy-to-navigate system lets you seamlessly organize local drug screening near Highland.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Highland drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Highland, in San Bernardino County, saw a 12% increase in drug-related arrests in 2022.
In San Bernardino County, Highland accounted for 15% of the opioid overdose cases reported in 2021.
Methamphetamine is the most commonly abused drug leading to hospitalization in Highland, CA.
Highland underwent a 20% rise in drug-related ER visits from 2020 to 2021.
The High Intensity Drug Trafficking Areas (HIDTA) program identified Highland as a key location for meth distribution in 2022.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Highland, CA, adopt rigorous drug testing policies to ensure a safe working environment. Many require pre-employment, random, and reasonable suspicion testing, aligning with federal guidelines provided by the Department of Transportation. Explore these guidelines here.
Local businesses, especially in sectors like transportation and healthcare, emphasize the importance of drug-free workplaces. Information on workplace testing can be accessed through the California Department of Industrial Relations website.
The government has intensified its efforts to tackle drug problems in Highland, CA, through the implementation of various programs. These include community outreach initiatives led by the San Bernardino County Department of Behavioral Health. For more information, visit their website here.
State-level actions, such as increased funding for rehabilitation programs, are supported by resources provided by the California Department of Health Care Services. Find details on their programs here.
In recent weeks, Highland, CA, has witnessed a series of drug busts, highlighting ongoing efforts to address illicit drug activities. Coordination between local law enforcement agencies and community tip-offs led to these successful operations, prioritizing neighborhood safety. These actions aim to diminish the influence of drug trafficking organizations within the city limits.
Community engagement has been crucial in combating drug-related issues in Highland. Residents have utilized hotlines and neighborhood watch programs to provide anonymous tips, bolstering police investigations. This collaboration reflects a dedicated community striving for safer environments and healthier living without the shadow of illegal substances.
The impact of these drug busts extends beyond immediate arrests. Law enforcement has seized significant quantities of methamphetamine and opiates, alongside firearms and cash, disrupting the supply chain. These confiscations send a strong message against drug proliferation, aiming to deter further illegal activities while promoting a drug-free community.
Following the recent crackdowns, Highland has initiated educational outreach programs focusing on prevention and recovery. Partnering with local schools and healthcare organizations, these programs emphasize awareness and support. They seek to provide a comprehensive approach to tackling drug issues, aiming to not only penalize but also educate and support affected individuals and families.
Accredited Drug Testing offers fast, reliable employment screening services in Highland, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
NIDA California Division
CDC California Overdose Data
California Health & Wellness
California Department of Health Care Services
San Bernardino County Substance Use Disorder Services
Reach Out Upland
Arrive Alive California
Riverside County Network of Care
SafeHouse of the Desert
Alcoholics Anonymous of California
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DNA testing for legal and non-legal purposes including child support, and child custody around Highland, CA.
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024