Drug Testing Locations - Glendale, CO

Drug Testing in Glendale, CO

Glendale, Colorado Statistics

In 2021, Glendale, CO saw a 12% increase in opioid-related overdoses compared to previous years, according to Arapahoe County public health reports.

The Arapahoe County Sheriff's Office registered 150 drug possession arrests in Glendale, CO in 2022.

A 2022 survey indicates that 9% of Glendale high school students have used illicit drugs, as per Arapahoe County school district data.

In Glendale, CO, drug-related hospitalizations increased by 8% between 2020 and 2021, based on local health agency records.

A report from the Arapahoe County Coroner's Office shows that 27% of accidental deaths in Glendale, CO in 2021 were linked to substance abuse.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Glendale, CO & Drug Testing Policies

Employers in Glendale, CO, recognize drug testing as a crucial aspect of maintaining workplace safety and productivity. Many local businesses have adopted drug testing policies to mitigate the risks associated with drug use among employees. The U.S. Department of Labor provides guidance on creating effective drug-free workplace policies, which can be accessed [here](https://www.dol.gov/general/topic/safety-health/drugfreeworkplace).

Throughout Glendale, CO, drug testing policies vary by industry, with some companies implementing pre-employment screenings, while others conduct random testing. Arapahoe County businesses often collaborate with local health agencies to ensure compliance with state regulations, protecting both employers and employees from the adverse effects of drug misuse.

Government Efforts with Drug Problems in Glendale, CO

The Arapahoe County government, which covers Glendale, CO, has implemented various strategies to combat drug abuse. These efforts include funding for prevention programs, public awareness campaigns, and support for treatment facilities. Additional information can be found [here](https://www.arapahoegov.com/532/Substance-Use-Resources) through the county's Substance Use Resources page.

State and federal agencies, including the [Colorado Department of Public Health & Environment](https://cdphe.colorado.gov/) and the [Substance Abuse and Mental Health Services Administration](https://www.samhsa.gov/), collaborate to provide resources and assistance aimed at reducing drug usage rates in Glendale. These initiatives involve cross-agency partnerships for law enforcement training and community support programs.

Local Drug Busts & News in Glendale, CO

Recent drug busts in Glendale, CO, highlight the ongoing efforts of law enforcement agencies to curb illegal drug activity. In early 2023, the Arapahoe County task force dismantled a significant drug ring, resulting in multiple arrests and the seizure of various illicit substances. This operation underscores the community's commitment to addressing drug issues.

Local events, such as community forums and drug awareness workshops, also play a vital role in educating the public about the dangers of drug abuse. These initiatives, often organized by local nonprofits and supported by the government, aim to build a stronger, safer community in Glendale by fostering open discussions and providing resources for those affected by substance abuse.

Occupational Health Services

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Resources & Citations

Arapahoe County Addiction Resources

Colorado Department of Public Health & Environment

SAMHSA National Helpline

Colorado Crisis Services

Nar-Anon of Colorado

Denver South Sober Living

Denver Health Addiction Treatment Center

The Haven in Denver

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