Drug Testing Locations - South Rockdale, GA

Drug Testing in South Rockdale, GA

South Rockdale, Georgia Statistics

In 2021, South Rockdale, GA, in Rockdale County, reported a 12% increase in drug arrests compared to the previous year.

Rockdale County's opioid-related deaths in 2020 accounted for 15% of all drug-related fatalities in South Rockdale, GA.

South Rockdale, GA, saw a 7% rise in methamphetamine use among adults between 2019 and 2021.

In 2020, there were over 300 drug-related emergency room visits in Rockdale County, with a significant portion originating from South Rockdale, GA.

According to a 2022 survey, 18% of high school students in South Rockdale, GA, reported experimenting with drugs.

South Rockdale, GA, in Rockdale County, noted a 20% increase in drug rehabilitation program enrollments in 2021.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in South Rockdale, GA & Drug Testing Policies

Employers in South Rockdale, GA, have heightened their focus on drug testing policies to ensure workplace safety and productivity. Many companies adhere to guidelines set forth by the U.S. Department of Labor and conduct pre-employment and random drug tests. These policies aim to deter drug use and maintain a stable workforce.

Moreover, local organizations collaborate with EEOC to ensure that their drug testing policies are compliant and do not discriminate against employees with a history of drug addiction who are in recovery. This approach helps support employees who seek rehabilitation while ensuring employers can maintain high standards.

Government Efforts with Drug Problems in South Rockdale, GA

In response to the growing drug issues in South Rockdale, GA, the local government has initiated various programs aimed at prevention and rehabilitation. One significant effort is the collaboration with CDC to enhance public health strategies and awareness. Additionally, Rockdale County has been working with the Georgia Department of Public Health to provide community resources for individuals affected by drug abuse.

Furthermore, the South Rockdale administration has partnered with the Office on Violence Against Women to address the intersection of drug abuse and domestic violence. They have also increased funding for local law enforcement to combat the drug trade actively. These efforts aim to create a safer and healthier environment for all residents.

Local Drug Busts & News in South Rockdale, GA

In recent years, South Rockdale has witnessed significant law enforcement actions targeting drug operations. For example, a major drug bust in early 2022 led to the seizure of over $1 million worth of narcotics. This operation was part of a broader initiative by the Rockdale County Sheriff's Office to dismantle drug networks.

Additionally, community events like the annual 'Drug Take-Back Day' have helped raise awareness and reduce the availability of prescription drugs that could be misused. This event, supported by the DEA, encourages residents to dispose of unused medications safely, mitigating potential abuse.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in South Rockdale, GA. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

Georgia Overdose Prevention

Georgia Department of Behavioral Health and Developmental Disabilities

Emory Healthcare Addiction Services

Narconon Drug Information for Georgia

Cartersville Recovery

Ray's Place Recovery Center

Pinnacle Treatment Centers - Rockdale House for Men

Recovery Rockdale County

Recovery.org Rockdale County

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