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Accredited Drug Testing delivers all-inclusive drug and alcohol testing solutions at our 35 testing sites in Makakilo City, Hawaii. Our services encompass DOT and non-DOT urine drug screenings, breath alcohol evaluations, EtG alcohol tests, and hair follicle analyses, catering to individuals, employers, and legal purposes. In Makakilo City, HI, we offer both rapid results testing and laboratory analyses accredited by SAMSA. Same-day services are accessible, with most testing centers just a short distance from your home or workplace. Our additional offerings cover Occupational Health Testing, Clinical Testing, and Background Verification.
Reach us at (800) 221-4291 or register via our website. By selecting your desired test and preferred location, you can arrange assessments for yourself, staff, or another person. Organizing a test is swift and simple—contact our scheduling team or book online any time, day or night. Our efficient and intuitive system facilitates effortless arrangement of drug testing services around Makakilo City.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Makakilo City drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Makakilo City, HI, Honolulu County, opioid-related overdoses have decreased by 15% from 2020 to 2023.
Approximately 30% of residents in Makakilo City, Honolulu County, are impacted by a family member's drug abuse.
Makakilo City, Honolulu County, saw a 12% increase in cannabis-related offenses in 2022 compared to 2021.
Honolulu County, including Makakilo City, reported 25 methamphetamine-related arrests in 2022.
In 2023, 40% of admissions to rehab centers in Makakilo City, Honolulu County, were alcohol-related.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Makakilo City, HI, are increasingly implementing drug testing policies to maintain a drug-free workplace. Many focus on pre-employment screening, ensuring candidates adhere to company standards. The Hawaii Department of Labor and Industrial Relations provides guidelines on conducting these tests while respecting employees' rights.
Local businesses benefit from guidance through state-funded programs that offer training and support for workplace drug policy implementation. Protocols often include mandatory drug testing following workplace accidents or when there is suspicion of substance abuse during working hours. This unified effort helps maintain workplace safety while promoting community wellness.
In Makakilo City, HI, various government efforts are underway to address drug problems. The Honolulu County Drug Court offers rehabilitation programs for non-violent offenders, emphasizing treatment over punishment. The Hawaii State Department of Health has initiated awareness campaigns targeting opioid misuse, resulting in a decrease in overdoses citywide.
The City and County of Honolulu collaborate with the Hawaii High-Intensity Drug Trafficking Area (HIDTA) program to combat drug trafficking networks. Additionally, local government units follow federal guidelines from agencies like the Drug Enforcement Agency to tackle substance abuse through continuous monitoring and law enforcement training.
Makakilo City, HI, experienced significant drug busts in 2023, reflecting ongoing vigilance by law enforcement. A notable operation took place in March in Honolulu County, where police seized large quantities of methamphetamine, leading to several arrests. This bust was part of a coordinated effort involving local and state authorities to disrupt major trafficking operations.
Another high-profile arrest occurred in July, targeting a heroin distribution ring that operated throughout Makakilo City and surrounding areas. The joint initiative between local police and federal agencies demonstrates the effectiveness of collaborative approaches. These successful interventions underscore the commitment to removing harmful substances from the streets.
Accredited Drug Testing offers fast, reliable employment screening services in Makakilo City, HI. Trusted by employers nationwide for accurate results and exceptional service.
Drug Rehab Hawaii
Hawaii o-drug Initiative
HHS Hawaii Programs
Hawaii Narcotics Anonymous
AA Hawaii
Hawaii n-drug Training
SMART Recovery Hawaii
Hawaii State Legislature
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025