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Accredited Drug Testing delivers extensive substance and alcohol testing at our 16 testing sites in Makawao, Hawaii. We cater to DOT and non-DOT urine drug testing, breath and EtG alcohol evaluations, and hair follicle drug screenings for personal, occupational, and legal purposes. In Makawao, HI, we offer prompt testing and SAMSA-approved lab reports, with same-day appointments available. Most centers are conveniently located near homes or workplaces. We also provide services like Occupational Health Testing, Clinical Assessments, and Background Screening.
Dial (800) 221-4291 or sign up online. Choose your preferred test and a local venue—ideal for personal, employee, or third-party screenings. Scheduling is quick and straightforward; contact our scheduling team or book online anytime. Our efficient and intuitive system ensures seamless drug testing arrangements near Makawao.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Makawao drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2021, Maui County reported a 15% increase in drug-related arrests, impacting areas like Makawao.
Makawao's youth witnessed an 8% rise in substance abuse cases, according to the 2020 Maui County Health Data.
Maui County highlighted in 2022 that 12% of drug-related emergencies came from Makawao residents.
A 2021 survey indicated that 20% of Makawao adults have misused prescription drugs at some point.
Makawao schools reported a 5% increase in drug-related incidents in 2022, as per Maui County Department of Education.
Maui County's 2020 health report showed Makawao contributing to 10% of overdose incidents countywide.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Makawao, HI, are increasingly recognizing the importance of maintaining a drug-free workplace to enhance productivity and ensure safety. Many businesses have adopted strict drug testing policies, often in compliance with state regulations, to prevent substance abuse in the workplace. These policies typically include pre-employment drug screenings and random testing during employment.
The State of Hawaii provides guidance on workplace drug testing policies, ensuring that employers adhere to legal standards. Information on how businesses can implement effective drug-free workplace policies is available through the Hawaii Workforce Development Division. This initiative helps both employers and employees navigate the complexities associated with substance abuse and its prevention in the workplace.
The government of Makawao, within Maui County, has been proactive in combating drug abuse through several initiatives. These include partnerships with local organizations and community outreach programs aimed at spreading awareness about the dangers of drug use. The Maui County Office of Economic Development offers resources to help those affected by drug abuse. Visit their official website for more information.
State-level initiatives also support Makawao in addressing drug problems. The Hawaii Department of Health has implemented statewide programs to reduce substance abuse through prevention and education. For additional resources and information, visit the Hawaii Department of Health.
In recent years, Makawao, HI has witnessed a series of drug busts aimed at curbing the spread of illegal substances within the community. Local police have made concerted efforts to collaborate with federal agencies, leading to the successful dismantling of several methamphetamine distribution rings. These operations often involve undercover work and the cooperation of informants, resulting in the seizure of significant quantities of drugs and weapons.
One notable event occurred when law enforcement officers executed a warrant at a suspected drug house, uncovering not only methamphetamine but also heroin and firearms. The bust was part of a wider initiative to stem the flow of drugs onto the island, which has seen an uptick in opioid abuse in recent years. The community has responded by increasing support services for addiction recovery and prevention programs.
Another significant arrest involved the capture of a high-profile drug trafficker who had been operating in the region for several years. This individual was implicated in a network that connected Makawao to larger operations on the mainland. The arrest was hailed as a crucial victory by local authorities, emphasizing the importance of continued vigilance and cooperation between different jurisdictional forces in the fight against drug-related crime.
Accredited Drug Testing offers fast, reliable employment screening services in Makawao, HI. Trusted by employers nationwide for accurate results and exceptional service.
Maui County Government
Hawaii Department of Health
Hawaii Substance Abuse Coalition
Hawaii Medical Service Association
Hawaii o-drug Initiative
Hoōpono - Addiction Recovery Services
Hana Health
Malama Recovery Clinic
SAMHSA
Hawaii Partnership to Prevent Underage Drinking
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025