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Accredited Drug Testing delivers wide-ranging drug and alcohol screening options across 6 locations near Puhi, Hawaii. Services include DOT and non-DOT urine tests, breathalyzer tests, EtG alcohol analysis, and hair-based drug assessments for personal, workplace, and legal purposes. Quick results testing is accessible in Puhi, HI along with SAMSA authorized lab assessments, offering same-day options; most Puhi sites are conveniently close to your residence or office. We also provide Occupational Health Tests, Clinical Evaluations, and Background Verification.
Dial (800) 221-4291 or register online for convenience. Select your desired test and a nearby testing center—options are available for self-use, employees, or others. Setting up a test appointment is seamless and swift. Contact our booking team or arrange your test online at any time. Our efficient and straightforward procedure facilitates easy drug test arrangements near Puhi.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Puhi drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2020, the drug-related arrest rate in Puhi, Kauai County was approximately 459 per 100,000 individuals.
Opioid-related hospitalizations in Puhi, Kauai County observed a 15% increase from 2018 to 2019.
In 2021, Kauai County reported over 200 cases of methamphetamine possession, affecting communities like Puhi.
The 2019 Kauai Health Department survey highlighted that 8% of adolescents in Puhi experimented with illicit drugs.
The rate of admissions for substance abuse treatment in Puhi, Kauai County increased by 11% from 2020 to 2021.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Puhi, Kauai County are implementing stringent drug-testing policies to ensure a safe working environment. Many facilitate pre-employment screenings and random drug tests to deter substance misuse within the workplace. The U.S. Equal Employment Opportunity Commission offers guidelines on fair testing practices.
Responding to growing concerns of drug-related incidences, some companies have initiated employee assistance programs aimed at supporting those struggling with addiction. These measures not only safeguard workplace integrity but also promote employee welfare through supplementary health services.
The government of Kauai County and local authorities in Puhi are actively working to combat drug misuse through several initiatives. Partnerships with organizations such as the Hawaii Police Department and the Hawaii Department of Health are pivotal in addressing these challenges.
Local programs aim to provide education and prevention efforts, with a focus on reducing substance abuse amongst youths. The introduction of community workshops and rehabilitation support is part of the strategic plan laid out by these organizations to foster a healthier population in Puhi.
Recent efforts by the Kauai Police Department have led to significant drug busts in Puhi, disrupting local drug networks. In February 2023, a collaborative operation resulted in the confiscation of substantial quantities of methamphetamine.
Awareness campaigns are also an integral part of community initiatives, with events aimed at educating the public about the dangers of drug use and the resources available for assistance. Such efforts underscore the commitment to eradicating drug dependency in Puhi, Kauai County.
Accredited Drug Testing offers fast, reliable employment screening services in Puhi, HI. Trusted by employers nationwide for accurate results and exceptional service.
Hawaii State Department of Health, Alcohol and Drug Abuse Division
Hilo Recovery Society
Kauai Behavioral Health
Kauai County Police
Hawaii o-drug Initiative
SAMHSA Hawaii Resource
Kapiolani Medical Center for Women & Children
Community Addiction Mental Health Services of Hawaii
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Customer service was surprisingly super helpful and so nice. She was able to get me in at a local location right away the same day. She helped me figure out exactly what I needed. Very impressed.
Brook - 9/19/2024
Fast and efficient service for employers wanting to do pre employment drug screening that meets DOT requirements!!
Mary Thomas - 4/5/2025
Where do I start?!! ADT is truly the best!! I had the pleasure of speaking with Tori today! She was excellent, professional and truly went above and beyond in her kind, compassionate care and commitment to providing me with the best service possible. I was in such a time crunch, but I was able to call, order the test, pay for it over the phone and get the test I needed within the hour. Not only did this put my mind at ease, they saved my job!! I am forever grateful for this team of hard workers, that care, with such great work ethics! Thank you from the very bottom of my heart!!! If you need a drug, alcohol, etc… screening, this team will be your lifesavers!!
Sarah Patterson - 4/8/2025