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At our 35 testing sites in Urban Honolulu, Hawaii, Accredited Drug Testing delivers all-inclusive drug and alcohol testing services. We cater to both DOT and non-DOT requirements with urine drug tests, breath alcohol checks, EtG alcohol analyses, and hair drug screenings. Whether for personal, employment, or legal reasons, we provide swift results with SAMSA certified lab evaluations. Most Urban Honolulu locations offer same-day service, conveniently situated near your residence or workplace. Our expanded offerings also cover Occupational Health Testing, Clinical Testing, and Background Checks.
Dial (800) 221-4291 or register online to choose a test and nearby site with ease—catering to individuals, staff, or third parties. Scheduling is simple and efficient; contact our scheduling team or arrange your test online any time, day or night. Our smooth, intuitive system ensures that arranging drug testing in Urban Honolulu is a breeze.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Urban Honolulu drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2021, Honolulu County reported a 15% increase in methamphetamine-related arrests compared to the previous year.
Urban Honolulu saw opioid-related hospital admissions rise by 20% in 2022, affecting local healthcare resources.
A 2023 survey showed that 18% of high school students in Honolulu County had used illicit drugs within the past year.
The use of fentanyl in Urban Honolulu has doubled since 2020, contributing to overdose deaths.
Honolulu County's drug courts have processed over 1,200 cases annually, a figure consistent with recent years.
In 2022, Urban Honolulu accounted for over 60% of drug trafficking offenses in the state of Hawaii.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Urban Honolulu, HI, are increasingly implementing stringent drug testing policies to ensure workplace safety and productivity. Companies may collaborate with agencies like the Hawaii Department of Labor and Industrial Relations to comply with state regulations regarding workplace drug policies.
Organizations across Honolulu County are adopting a range of testing methods including pre-employment, random, and post-incident drug tests. Employers aim to deter substance abuse and maintain a safe environment for all employees.
The government of Urban Honolulu, HI, has been proactive in addressing the drug problem through various initiatives. The Honolulu Mayor's Office works closely with the Hawaii Department of Health to promote substance abuse prevention programs targeting youths and at-risk groups.
Efforts also include collaborations with federal agencies such as the Drug Enforcement Administration to combat trafficking and distribution networks. These partnerships focus on both enforcement and rehabilitation strategies to reduce the impact of drug abuse in communities across Honolulu County.
Over recent years, Urban Honolulu, HI, has witnessed several significant drug busts, reflecting ongoing efforts to curtail narcotics trafficking. In a notable 2022 operation, local authorities seized substantial quantities of methamphetamine, arresting multiple individuals linked to drug cartels.
These actions, often facilitated by joint task forces, highlight the collaboration between local law enforcement and federal agencies to dismantle major drug operations. Such efforts are crucial in combating the availability and distribution of illegal substances across Honolulu County.
Accredited Drug Testing offers fast, reliable employment screening services in Urban Honolulu, HI. Trusted by employers nationwide for accurate results and exceptional service.
Honolulu Police Department
Substance Abuse and Mental Health Services Administration
Hawaii Substance Abuse Prevention
Hawaii County Substance Abuse Program
National Association for Children of Addiction
National Institute on Drug Abuse
Partnership to End Addiction
Centers for Disease Control and Prevention
Parents and Children Together Hawaii
Aunt Bertha: Connect to Social Services
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025