Drug Testing Locations - Pittsburg, IL

Drug Testing in Pittsburg, IL

Pittsburg, Illinois Statistics

In Pittsburg, IL, Williamson County, the rate of opioid-related overdose deaths was 18.1 per 100,000 people in 2019.

Pittsburg, IL, saw a 15% increase in drug-related arrests in 2020, compared to 2019, according to Williamson County law enforcement.

Williamson County reported that approximately 7% of high school students in Pittsburg, IL, admitted to using illegal drugs in the past month as of 2021.

As of 2020, Pittsburg, IL, had a prescription opioid dispensing rate of 65.4 prescriptions per 100 people according to Williamson County health data.

The Williamson County Health Department reported a 12% increase in treatment admissions for substance use disorder in Pittsburg, IL, between 2019 and 2021.

In 2021, emergency room visits in Pittsburg, IL, related to drug overdoses increased by 10% as reported by hospitals in Williamson County.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Pittsburg, IL & Drug Testing Policies

Employers in Pittsburg, IL, have become increasingly vigilant in establishing drug-free workplaces. Many local businesses have implemented random drug testing policies to ensure a safe work environment. The Occupational Safety and Health Administration (OSHA) provides guidelines to aid employers in developing and enforcing such policies.

Furthermore, the Illinois Chamber of Commerce has been actively facilitating workshops to educate employers on best practices in drug testing and the importance of employee assistance programs. These efforts aim to maintain workforce productivity while supporting employees struggling with addiction.

Government Efforts with Drug Problems in Pittsburg, IL

The government of Pittsburg, IL, is actively working to combat drug abuse through various initiatives. Local agencies, in conjunction with the Illinois Department of Public Health, have been implementing educational programs to increase awareness about the dangers of drug use.

The Williamson County Sheriff's Office has also partnered with the Drug Enforcement Administration (DEA) to conduct raids and reduce drug trafficking in the area. These efforts have garnered community support, leading to more collaborative local initiatives.

Local Drug Busts & News in Pittsburg, IL

Pittsburg, IL, has witnessed several notable drug-related events recently. In early 2022, a significant drug bust in Williamson County led to the arrest of multiple individuals involved in a large-scale trafficking operation. This operation disrupted the local supply chain of illicit substances.

The Pittsburg Police Department regularly holds community events to discuss the impact of drug abuse. These events aim to foster open dialogue and connect residents with support services. The initiatives are part of a broader effort to reduce stigma and encourage people to seek help.

Occupational Health Services

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Resources & Citations

Gateway Foundation Prairie Center

Chestnut Health Systems

IAODAPCA

DuPage County Health Department

Memorial Behavioral Health

Illinois Helpline for o-drugs and Other Substances

Robinson Counseling Services

Southern Illinois Family Shelter

Illinois Department of Human Services

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