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Accredited Drug Testing facilitates a broad range of drug and alcohol testing services at our 36 centers situated around Argo, Kentucky. We cater to DOT and non-DOT requirements with urine drug screens, breath alcohol analysis, EtG alcohol screenings, and hair drug tests for personal, corporate, and court-related purposes. Enjoy quick result testing and SAMSA-lab certified assessments available in Argo, KY. Immediate service is possible at most Argo facilities, typically a short distance from wherever you are. We also provide Occupational Health Testing, Clinical Analysis, and Background Verification.
Dial (800) 221-4291 or register online for services. Choose your desired test and the closest center—ideal for personal, employee, or third-party testing. Test scheduling is swift and straightforward, via our scheduling line or online 24/7. Enjoy a smooth and efficient process to organize drug tests near Argo with ease.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Argo drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2020, Argo, KY in Jefferson County reported a 25% increase in drug overdose deaths.
Argo, KY has seen a significant rise in opioid-related hospital visits, with a 30% increase in the past three years.
In Jefferson County, KY, methamphetamine usage rates have doubled since 2018.
A survey from 2021 revealed that 15% of Argo's high school students reported trying illicit drugs at least once.
Public safety reports in Argo, KY note a 40% increase in drug-related criminal activities over the last two years.
Drug abuse treatment facilities in Jefferson County, KY, have seen a 50% increase in admissions since 2019.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Argo, KY, have increasingly adopted stringent drug testing policies to ensure a safe and productive work environment. Many firms are aligning with state guidelines provided by U.S. Department of Labor on maintaining drug-free workplaces. Random drug testing and pre-employment screenings are standard practices for businesses in Jefferson County.
Larger employers in Argo collaborate with local health agencies to provide drug education and rehabilitation resources to employees. This holistic approach aims not only to maintain safety but also to support employees in overcoming substance abuse challenges, thus promoting wellness within the community.
In an effort to address the growing drug problem in Argo, KY, the local government has ramped up collaboration with organizations like SAMHSA and increased funding for community outreach programs. Through educational initiatives and partnerships with health services, there's a concerted push to reduce the rates of drug dependence in Jefferson County.
The state government has also implemented stricter regulations on prescription medications to prevent misuse. Resources like Kentucky Office of Drug Control Policy are vital in these efforts, providing guidelines and funding to local authorities in Argo to tackle opioid addiction comprehensively.
Recently, law enforcement agencies in Argo, KY made a significant drug bust, leading to the seizure of large quantities of methamphetamines and several arrests. These operations are part of ongoing efforts by local police departments and task forces to curtail drug trafficking in Jefferson County.
Community events in Argo frequently focus on awareness of the dangers of drug abuse, often facilitated by local nonprofits. These events highlight personal stories, educate on the signs of substance abuse, and promote available treatment options, playing a crucial role in community prevention strategies.
Accredited Drug Testing offers fast, reliable employment screening services in Argo, KY. Trusted by employers nationwide for accurate results and exceptional service.
Kentucky State Police
Kentucky Justice and Public Safety Cabinet
KIPDA Area Agency on Aging and Independent Living
Nar-Anon Family Groups
Faces and Voices of Recovery
New Vista Behavioral Health
The Arc of Kentucky
Bluegrass Behavioral Health Services
Cumberland River Behavioral Health
Volunteers of America Mid-States
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024