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Accredited Drug Testing provides a full array of drug and alcohol testing services at our 30 testing facilities around Fayette, Kentucky. Our offerings include DOT and non-DOT urine analyses, breath alcohol exams, EtG tests, and hair screenings tailored for individuals, businesses, and legal contexts. In Fayette, KY, we deliver rapid testing outcomes and SAMSA laboratory diagnostics. Swift service is available, with most Fayette centers conveniently situated close to your home or work. Further services encompass Occupational Health Evaluations, Clinical Screenings, and Background Verifications.
Reach out at (800) 221-4291 or register online. Pick your preferred test, then select a nearby center—testing caters to personal, employee, or other needs. Arranging a test is quick and straightforward; contact our scheduling team or set up your test via our online system anytime. Our efficient, easy-to-use approach facilitates stress-free drug testing setup in Fayette.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Fayette drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Fayette County, KY, opioid prescriptions decreased by 15% between 2019 and 2022.
Fayette County reported over 500 drug overdose-related ER visits in 2021.
Lexington, located in Fayette County, saw a 12% increase in fentanyl-related overdoses in 2022.
In 2021, Fayette County had an opioid-related death rate of 39 per 100,000 residents.
The city of Lexington in Fayette County experienced a 20% decline in methamphetamine seizures from 2021 to 2022.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Fayette County, KY, have implemented stringent drug testing policies to ensure workplace safety. Many companies collaborate with the U.S. Department of Labor for guidelines on testing standards. This includes pre-employment screenings and random testing to maintain a drug-free environment.
Implementing comprehensive drug-free workplace policies, employers are proactive in preventing drug-related issues. They offer employee assistance programs to support those with drug addiction challenges, aiming for recovery and integration back into a safe work environment.
Fayette County employers are also involved in community outreach programs that educate workers on the dangers of drug abuse. By fostering a supportive culture, they aim to make a significant impact on reducing drug dependency among employees.
The government of Fayette County, KY, has been ramping up its efforts to combat drug abuse through several initiatives. They have collaborated with the Kentucky Cabinet for Health and Family Services to improve access to treatment programs. New policies focus on both prevention and recovery to tackle the opioid crisis affecting the region.
Working alongside local agencies, Fayette County received grants aimed at bolstering public health responses. These government efforts focus on reducing the incidence of drug abuse through community education and support services. Additionally, the government supports harm reduction programs to save lives and improve public safety.
In Fayette County, KY, local law enforcement agencies have intensified their efforts to combat the ongoing drug crisis. Recent operations have resulted in significant seizures of illicit substances, including methamphetamine and heroin. These efforts are part of a broader strategy aimed at dismantling drug networks and curbing the rise in overdose cases, which have been a growing concern for the community.
Several coordinated raids across the county have led to numerous arrests, targeting both street-level dealers and mid-level distributors. This approach not only disrupts the immediate supply chain but also aims to gather intelligence that could lead to the identification of higher-level drug traffickers operating within and beyond the local jurisdiction.
Community engagement remains a key component in the fight against drug abuse in Fayette. Local authorities have been working alongside public health officials to promote awareness and provide resources for addiction treatment and rehabilitation. These initiatives are critical in offering support to individuals struggling with substance abuse, thus reducing demand and aiding in the overall reduction of drug-related incidents.
Accredited Drug Testing offers fast, reliable employment screening services in Fayette, KY. Trusted by employers nationwide for accurate results and exceptional service.
Bluegrass.org
Centerstone
Lexington Recovery
Recovery Awareness of Northern & Southern Central Kentucky
Volunteers of America Mid-States
Shepherd's House
NKY Hates Heroin
ADA of Lexington
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024