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Accredited Drug Testing provides extensive drug and alcohol testing services through our 17 testing sites in the Industry, Maine region. We conduct both DOT and non-DOT urine drug tests, breath alcohol assessments, EtG alcohol screenings, and hair drug tests tailored for individuals, businesses, and legal purposes. Our rapid results testing and SAMSA accredited lab analysis in Industry, ME ensures quick turnaround, with many testing facilities conveniently located near your home or workplace. We also offer Occupational Health Testing, Clinical Testing, and Background Checks.
Contact us at (800) 221-4291 or sign up online. Just pick your required test and select a convenient location—available for personal use, employee screening, or third-party testing. Scheduling is swift and straightforward, either through our scheduling department or the 24/7 online system. Our efficient, user-friendly process simplifies organizing drug tests in Industry.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Industry drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in the manufacturing industry have often prioritized safety and productivity, leading to the implementation of stringent drug testing policies. These policies are designed to ensure a safe workplace and are often guided by federal agencies. For more information on workplace safety regulations, visit the OSHA website.
In the state of Maine (ME), employers must navigate both state and federal guidelines when it comes to drug testing. Maine has specific rules that employers must follow to legally conduct drug tests, as outlined by the Maine Department of Labor. Ensuring compliance is crucial for maintaining legal operations within the state.
Federal drug testing policies often cover various aspects from testing procedures to privacy regulations. The Substance Abuse and Mental Health Services Administration is a key federal body offering guidelines on drug testing. For detailed federal guidelines, you can visit the SAMHSA webpage.
The government has actively worked to address the drug crisis impacting industries in Maine. Statewide initiatives focus on prevention, treatment, and recovery support. The Maine Department of Health and Human Services plays a pivotal role, launching programs aimed at reducing substance abuse and providing resources for affected workers.
On a national level, federal agencies collaborate with businesses to ensure compliance with drug-free workplace policies. The Substance Abuse and Mental Health Services Administration offers guidance and tools to industries, emphasizing rehabilitation and employee assistance programs. This multi-layered approach is crucial in mitigating the impact of drugs on both workers and productivity.
In recent events, Industry, ME has unfortunately seen an uptick in drug-related activities, prompting a series of local drug busts. These efforts by law enforcement aim to stem the flow of illegal substances into the community. Residents have reported concerns over increasing drug visibility, leading to heightened collaboration between local police and community organizations dedicated to public safety and awareness.
This past month, a significant operation led to the apprehension of several suspects allegedly involved in drug trafficking within Industry, ME. The operation uncovered substantial quantities of illegal narcotics, highlighting the crucial role local law enforcement plays in combating the drug menace. These arrests mark a pivotal step in curbing the inflow of drugs and addressing community concerns regarding safety and health risks.
Community meetings have become a focal point for discussion in Industry, ME as residents seek to address the underlying issues fueling drug-related activities. Officials are engaging with schools, local businesses, and social services to formulate comprehensive strategies that focus on prevention and rehabilitation. Public involvement is seen as essential in creating a safer environment and supporting those affected by addiction.
Accredited Drug Testing offers fast, reliable employment screening services in Industry, ME. Trusted by employers nationwide for accurate results and exceptional service.
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DNA testing for legal and non-legal purposes including child support, and child custody around Industry, ME.
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025