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Accredited Drug Testing provides a wide array of drug and alcohol screening services through our 8 testing facilities in Topsfield, Maine. Our offerings include DOT and non-DOT urine tests, breathalyzer exams, EtG alcohol tests, and hair drug analyses to accommodate personal, employment, and legal requirements. Get rapid result tests and SAMSA-certified lab assessments in Topsfield, ME, with same-day service available. Most testing sites are conveniently close to your residence or workplace. We also offer Occupational Health Checks, Clinical Testing, and Background Screening.
To schedule, dial (800) 221-4291 or go online. Choose your test, pick a convenient site—services are available for yourself, employees, or others. With quick and simple scheduling, our team assists via phone or through our 24/7 online portal. Our efficient and intuitive system ensures you can easily arrange drug testing near Topsfield.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Topsfield drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Topsfield, ME, part of Washington County, opioid-related deaths increased by 15% in 2022.
Topsfield, ME, reported a 10% rise in drug rehab admissions in Washington County in the past year.
Washington County, home to Topsfield, ME, saw 50 opioid overdose cases in 2022.
In 2022, Topsfield, ME, experienced a 20% increase in methamphetamine-related arrests.
Topsfield, ME, in Washington County, saw a decline in needle exchange participation by 5% in 2022.
Heroin use rose by 8% among residents of Topsfield, ME, in Washington County, last year.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Topsfield, ME, are increasingly adopting rigorous drug testing policies to maintain workplace safety and productivity. These policies help identify employees in need of support while ensuring a drug-free environment. The emphasis is on rehabilitation over punitive measures, aligning with broader state health goals.
Drug testing policies in Washington County focus on both pre-employment and random tests. Employers collaborate with local health authorities to ensure compliance with state regulations. The goal is to balance safety with support for employees battling addiction, which aligns with Maine's statewide efforts as outlined by the Maine Department of Labor.
The government of Topsfield, ME, in collaboration with Washington County, is taking significant steps to address drug-related issues. Initiatives include funding for rehabilitation centers and expanded access to mental health services. These efforts aim to reduce addiction rates and assist in recovery.
State and local programs are providing education and preventive measures targeting young residents in Topsfield. The community is actively engaging with state-wide initiatives, fostering partnerships that include both governmental and non-governmental organizations. More information can be found at the Maine Department of Health and Human Services.
In a major crackdown, Topsfield, ME, witnessed several drug busts in 2022, which were aimed at dismantling distribution networks in Washington County. These operations were coordinated by local and state law enforcement agencies, leading to multiple arrests.
The increased drug-related events have prompted heightened surveillance and community programs aimed at prevention. Local authorities, alongside state initiatives, are focusing on increasing awareness and reducing drug-related activities. These efforts have begun yielding positive results, reflected in declining crime rates associated with drug abuse.
Accredited Drug Testing offers fast, reliable employment screening services in Topsfield, ME. Trusted by employers nationwide for accurate results and exceptional service.
Maine Office of Substance Abuse and Mental Health Services
Maine Administrative Rules: Substance Abuse
Maine Association of Substance Abuse Programs
Maine Prevention Store
Maine Drug Enforcement Agency
Maine Drug Data Hub
Community Health Options: Substance Use Resources
Northern Light Health: Substance Use and Mental Health Resources
Portland Recovery Community Center
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025