Drug Testing Locations - Garrett Park, MD

Drug Testing in Garrett Park, MD

Garrett Park, Maryland Statistics

Garrett Park, Montgomery County reports a 15% increase in opioid-related deaths from 2017 to 2022.

In 2021, marijuana possession arrests in Garrett Park, Montgomery County declined by 10% compared to 2020.

Montgomery County's Garrett Park saw a 25% rise in substance abuse treatment admissions from 2019 to 2021.

Naloxone administration in Garrett Park increased by 30% between 2020 and 2022 according to Montgomery County data.

Underage drinking citations in Garrett Park, Montgomery County have decreased by 8% in the last year.

In 2022, Garrett Park in Montgomery County reported a 5% decrease in drug-related school suspensions compared to 2021.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Garrett Park, MD & Drug Testing Policies

Employers in Garrett Park, MD, have adopted stringent drug testing policies to ensure a safe workplace. Many companies utilize pre-employment screening, random drug testing, and post-incident drug tests as preventive measures. These policies align with state guidelines to mitigate workplace drug abuse concerns.

Montgomery County encourages organizations in Garrett Park to implement comprehensive Employee Assistance Programs (EAPs) to support employees struggling with substance abuse issues. Such programs are designed to provide counseling and rehabilitation options, which can help in retaining valuable employees.

Government Efforts with Drug Problems in Garrett Park, MD

The government of Garrett Park, MD has implemented various initiatives to address the drug problem. Montgomery County has programs aimed at increasing public awareness and providing access to resources. Montgomery County Addiction Services offers various resources to residents.

Collaborative efforts with state agencies have strengthened local responses to drug abuse through funding and policy changes. State support is visible through initiatives like the Maryland Opioid Operational Command Center which extends its services to spaces around Garrett Park to mitigate drug-related issues with a focus on public health and law enforcement partnerships.

Local Drug Busts & News in Garrett Park, MD

Local law enforcement in Garrett Park, MD, has reported several significant drug busts in recent years. In 2022, a coordinated effort led to the arrest of multiple individuals involved in narcotics distribution within Montgomery County. This operation was pivotal in reducing the availability of illicit drugs in Garrett Park.

The community responds to these events through town hall meetings and increased cooperation with police and local government. These collaborative efforts aim to strengthen the neighborhood's resilience against drug-related activities, fostering a safer environment for residents.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Garrett Park, MD. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

Montgomery County Addiction Services

Maryland Department of Health Behavioral Health Administration

MedChi Maryland State Medical Society

Maryland Coalition Against Sexual Assault

Hope Therapy Center of Maryland

Prevention Works Maryland

Maryland Psychiatric Research Center

Montgomery County Crisis Center

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