Drug Testing Locations - Birmingham, MI

Drug Testing in Birmingham, MI

Birmingham, Michigan Statistics

In Birmingham, Oakland County, 15% of high school students reported using illicit drugs in the past month.

Oakland County's Birmingham reported a 20% increase in opioid-related ER visits between 2021 and 2022.

Birmingham, MI, in Oakland County, saw a 5% rise in drug-related arrests in 2022.

The number of drug overdose deaths in Birmingham, Oakland County, doubled in 2021 compared to prior years.

Birmingham, MI, located in Oakland County, witnessed a 10% rise in heroin-related incidents in 2022.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Birmingham, MI & Drug Testing Policies

Employers in Birmingham, MI, recognize the importance of maintaining a drug-free workplace. Many have instituted drug testing policies as part of their efforts to curb substance abuse, both pre-employment and randomly, to ensure a safe and productive work environment. Businesses often follow guidelines from the Michigan Workforce Development Agency (WDA) for best practices in employment policies.

Additionally, some Birmingham employers offer Employee Assistance Programs (EAPs) that provide support and resources for employees struggling with addiction issues. These programs highlight a commitment to employee well-being and community safety, aligning with broader statewide initiatives to combat drug abuse.

Government Efforts with Drug Problems in Birmingham, MI

In Birmingham, MI, local government agencies have implemented several strategies to address the drug problem. Collaborative efforts with Oakland County’s health services aim to provide better access to addiction resources and support, emphasizing prevention and education. The city supports various community-based programs that focus on rehabilitation and recovery.

State-level initiatives from the Michigan Department of Health and Human Services (MDHHS) align with Birmingham's local strategies to combat drug abuse. These include grants for substance use disorder services and partnerships with non-profit organizations to enhance outreach and community awareness.

Local Drug Busts & News in Birmingham, MI

In a recent operation, law enforcement agencies in Birmingham, MI successfully dismantled a major drug trafficking network. The bust led to the seizure of significant quantities of illicit substances, including heroin and methamphetamine. This operation was part of a larger initiative to combat the rising drug-related activities in the region, aiming to enhance community safety and well-being.

Earlier this year, Birmingham police conducted a series of raids targeting high-risk locations known for drug trade activities. These efforts resulted in multiple arrests and the confiscation of various narcotics and illegal firearms. Authorities attribute these actions to cooperative investigative work and intelligence sharing among local agencies.

Community leaders and residents in Birmingham have expressed support for the ongoing efforts to address drug abuse and trafficking. Educational programs and workshops are being organized to raise awareness about the dangers of drug use. These initiatives are also focusing on providing resources for rehabilitation and recovery for those affected by substance abuse.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Birmingham, MI. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

Michigan Association of Alcoholism and Drug Abuse Counselors

Oakland County Health Division

Families Against Narcotics

Michigan Department of Health & Human Services

Community Recovery Alliance

Birmingham Covington School Resources

Nar-Anon Family Groups

Oxford Recovery Center

Recovery.org

Addiction Center

Drug Testing Near Birmingham, MI

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