Drug Testing Locations - Craig, NE

Drug Testing in Craig, NE

Craig, Nebraska Statistics

In Craig, NE, part of Burt County, opioid-related hospital visits increased by 25% from 2018 to 2022.

The substance abuse treatment admission rate in Craig, NE, Burt County, rose by 15% between 2017 and 2021.

Methamphetamine-related arrests accounted for 40% of drug arrests in Craig, NE, Burt County in 2021.

In Burt County, home to Craig, NE, 30% of DUI arrests involved drug impairment in 2020.

Craig, NE, Burt County, saw a 50% increase in heroin overdoses between 2019 and 2022.

The rate of drug-induced deaths in Burt County, including Craig, was 12 per 100,000 people in 2021.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Craig, NE & Drug Testing Policies

Employers in Craig, NE, recognize the impact of drug abuse on the workforce and have implemented stringent drug testing policies. Many businesses conduct pre-employment, random, and post-accident drug tests to foster a safe work environment. Compliance with state and federal regulations, such as those from the Occupational Safety and Health Administration, is carefully maintained.

Some employers work closely with the community and local organizations to offer support programs for employees struggling with addiction. By providing access to counseling and rehabilitation services, they aim to ensure recovery and retention of skilled workers. This approach aligns with initiatives by the Substance Abuse and Mental Health Services Administration.

Government Efforts with Drug Problems in Craig, NE

The government of Craig, NE, in collaboration with Burt County, has intensified efforts to combat drug abuse through various initiatives. These include enhanced funding for rehabilitation centers and preventive education programs targeting young individuals. Local agencies work with the Nebraska Department of Health and Human Services to expand access to mental health services.

In recent years, local law enforcement has partnered with state and federal agencies to address drug trafficking. Enhanced training and resources have been provided to officers in Craig, NE, as part of the state's comprehensive approach, in line with guidelines from the Drug Enforcement Administration.

Local Drug Busts & News in Craig, NE

Recent drug busts in Craig, NE, have highlighted the ongoing issue of drug trafficking within Burt County. In 2022, local law enforcement successfully seized significant quantities of methamphetamine and arrested several key figures involved in drug distribution networks. These operations, often conducted in collaboration with state and federal agencies, underscore the region's commitment to tackling drug-related crime.

Public awareness events are frequently organized in Craig, NE, aiming to educate residents about the dangers of drug abuse and the resources available for assistance. These events are part of broader community strategies to mitigate drug problems and are supported by organizations such as Project Extra Mile, which focus on prevention and community outreach.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Craig, NE. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

National Institute on Drug Abuse

Nebraska Prevention Information

Nebraska Department of Health and Human Services

Lincoln-Lancaster County Health Department

Office of Governor Pete Ricketts

Nebraska Coalition

Omaha Women's Fund

Project Extra Mile

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