Drug Testing Locations - Union, NH

Drug Testing in Union, NH

Union, New Hampshire Statistics

In Union, NH, situated in Carroll County, emergency room visits related to drug overdoses increased by 15% last year.

Union, NH saw a 20% rise in opioid-related deaths according to the Carroll County health department's 2022 report.

The number of drug-related arrests in Union, NH doubled over the past three years as reported by the local police department.

Carroll County reported that nearly 30% of Union's teenagers have tried illicit drugs, with marijuana being the most popular.

Union, NH's drug-related crime rate in 2022 was the second highest within Carroll County, primarily due to heroin and methamphetamine.

The Carroll County health department reported a 25% increase in drug treatment program enrollments from Union, NH last year.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Union, NH & Drug Testing Policies

In Union, NH, employers are increasingly implementing stringent drug testing policies to maintain a safe and productive workplace. Local businesses often conduct pre-employment and random drug tests to identify and address substance abuse issues among employees. For more information, employers can refer to the New Hampshire Department of Labor.

These drug testing policies aim to deter the use of illicit substances and ensure compliance with federal and state regulations. Union employers may also offer Employee Assistance Programs (EAPs) to support employees struggling with substance abuse, providing them with resources and counseling services.

Government Efforts with Drug Problems in Union, NH

The government in Union, NH has been intensifying efforts to address drug problems through various initiatives. For instance, the local government collaborates with the New Hampshire Department of Health and Human Services to enhance access to treatment programs. Additionally, Union has initiated community outreach campaigns to increase awareness and reduce stigma surrounding addiction.

At the state level, New Hampshire State authorities have allocated additional funding for drug-related education and prevention programs in Union, NH. The state government also encourages collaboration with federal agencies like the Substance Abuse and Mental Health Services Administration (SAMHSA) to improve access to mental health services.

Local Drug Busts & News in Union, NH

Recently, Union, NH has seen an increase in local drug busts and related events. The Carroll County Sheriff's Office reported several significant drug seizures this year, which focused on dismantling local distribution networks of substances such as heroin and methamphetamine.

In one notable event, local authorities collaborated with federal agencies to arrest multiple individuals linked to a drug trafficking ring operating in and around Union, NH. These efforts reflect the ongoing commitment of law enforcement to combat drug-related crime and improve community safety.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Union, NH. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

NH Department of Health and Human Services

Drug Free New Hampshire

New Hampshire Center for Excellence

NH Treatment Locator

Recovery Friendly Workplace Initiative

The Phoenix New Hampshire

Families in Transition New Hampshire

Granite Pathways

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