Drug Testing Locations - Chester, NJ

Drug Testing in Chester, NJ

Chester, New Jersey Statistics

Chester, NJ, in Morris County, reported a 15% increase in opioid-related hospital visits in 2022.

In 2021, Chester, NJ, had a 22% rise in drug-related arrests compared to the previous year.

Morris County, where Chester is located, saw 54 drug overdose deaths in 2021.

Chester, NJ schools reported a 10% increase in substance abuse incidents among students in 2021.

In 2022, the Chester Police Department conducted 50 drug awareness workshops within the community.

Morris County reported a 5% decrease in drug-related accidents in 2023 compared to 2022.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Chester, NJ & Drug Testing Policies

Employers in Chester, NJ, are increasingly implementing stringent drug testing policies to ensure workplace safety. Many companies adhere to state laws requiring random and pre-employment drug screenings. Information on workplace drug policies can be found at the National Conference of State Legislatures.

Local businesses often align with guidelines from the Occupational Safety and Health Administration (OSHA), which emphasize drug-free workplaces. Effective policies are crucial in maintaining productivity and reducing liability (OSHA policies available here).

Additionally, Chester employers engage in periodic workforce training, addressing substance abuse signs and prevention, further supporting the community's health and safety goals.

Government Efforts with Drug Problems in Chester, NJ

The government of Chester, NJ, in collaboration with Morris County officials, has implemented various initiatives to combat drug problems. These include the Morris County Prevention is Key program, which provides resources and education on substance abuse (see MCPiK).

Furthermore, the Chester Police Department actively participates in the D.A.R.E. program, focusing on drug resistance education for youth. State-level support also comes from the NJ Department of Human Services, offering grants to local initiatives (more info here).

Local Drug Busts & News in Chester, NJ

Chester, NJ, has experienced notable drug-related events, including a major bust in early 2023, where local law enforcement seized significant quantities of illicit drugs. This operation was a joint effort with Morris County's Narcotics Task Force, leading to multiple arrests.

The community actively participates in semi-annual drug take-back events, organized in collaboration with the DEA. Such initiatives aim to reduce the availability of unused prescription drugs on the streets (see DEA Take Back Day).

Public awareness events, like the Chester Drug Seminar held annually, focus on education and prevention strategies. These efforts include participation from local schools, health professionals, and law enforcement.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Chester, NJ. Trusted by employers nationwide for accurate results and exceptional service.

New Jersey DOT/Non DOT Physicals

New Jersey Vision Tests

New Jersey Audiograms

New Jersey Respirator Fit Tests

New Jersey Lift Tests

New Jersey Background Checks

Clinical Testing Services

TB Testing in NJ

Diabetes Testing in NJ

Infectious Disease Testing in NJ

Sickle Cell Anemia Testing in NJ

Women/Men's Health Testing in NJ

Resources & Citations

NJ Addiction Services

Morris County Prevention is Key

NJ 2-1-1 Addictions

Center for Prevention

NCADD New Jersey

Daytop New Jersey

NJ Mental Health Cares

Morris County Health

Drug Testing Near Chester, NJ

Mount Olive, NJ

Lamington, NJ

Mendham, NJ

Brookside, NJ

Bernardsville, NJ

Flanders, NJ

Far Hills, NJ

Bedminster, NJ

Ironia, NJ

Long Valley, NJ

Ralston, NJ

Pottersville, NJ

Peapack, NJ

Gladstone, NJ

Frequently Asked Questions

Customer Reviews