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Accredited Drug Testing provides a full range of drug and alcohol testing services at 31 locations in the Upper Saddle River, New Jersey vicinity. Our services include DOT and non-DOT urine drug testing, breathalyzer tests, EtG alcohol tests, and hair drug analyses for personal, occupational, and legal purposes. We facilitate both instant result testing and SAMSA certified lab evaluations in Upper Saddle River, NJ. Most of our test sites are conveniently located near homes or workplaces, with same-day service availability. Our additional offerings involve Occupational Health Testing, Clinical Testing, and Background Screening.
Reach us at (800) 221-4291 or register online. Choose your desired test and a nearby testing center—ideal for personal, employee, or third-party screening. Setting up a test is seamless and convenient: contact our scheduling team or book your test any time online. Our efficient and intuitive process facilitates easy drug testing arrangements near Upper Saddle River.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Upper Saddle River drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In recent years, Upper Saddle River, located in Bergen County, reported a 15% increase in drug-related arrests.
Upper Saddle River in Bergen County has seen a 10% rise in opioid-related emergency room visits.
Bergen County officials recorded a 20% increase in drug overdose fatalities in Upper Saddle River.
Teen drug abuse cases in Upper Saddle River, Bergen County, rose by 8% over the past five years.
Police in Upper Saddle River responded to an average of 30 drug-related incidents annually in Bergen County.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
In Upper Saddle River, NJ, employers often implement strict drug testing policies to ensure workplace safety. The New Jersey Department of Labor and Workforce Development provides guidelines for employers, found here.
Many businesses in Upper Saddle River require pre-employment drug testing, and some also conduct random testing to maintain a drug-free workplace. The New Jersey State Chamber of Commerce supports businesses in their efforts, details of which can be seen here.
The government of Upper Saddle River, NJ, collaborates with Bergen County authorities to tackle drug abuse through educational programs and support networks. For more information, visit the Bergen County official website.
Statewide initiatives from New Jersey's Department of Human Services focus on prevention and recovery services accessible to Upper Saddle River residents. Learn more at the NJ DHS website.
In a significant operation, local authorities in Upper Saddle River, NJ, successfully dismantled a drug distribution network. This bust, which took place last month, led to the seizure of multiple kilos of illicit substances and the arrest of several key figures involved in the network. Law enforcement officials have stated that this operation marks a critical step in curbing drug-related activities in the area.
The Upper Saddle River community has been vigilant in reporting suspicious activities, which played a crucial role in the recent success of the anti-drug enforcement operations. The local police department encourages residents to continue their cooperation, emphasizing the importance of community involvement in maintaining a safe and drug-free neighborhood.
Recent drug-related events have also highlighted the importance of educational programs in Upper Saddle River, NJ. Local schools have partnered with nonprofit organizations to raise awareness among youth about the dangers of drug use. These initiatives aim to equip students with the knowledge and resources to resist peer pressure and make informed decisions.
Accredited Drug Testing offers fast, reliable employment screening services in Upper Saddle River, NJ. Trusted by employers nationwide for accurate results and exceptional service.
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024