Drug Testing Locations - El Cerro, NM

Drug Testing in El Cerro, NM

El Cerro, New Mexico Statistics

In 2021, 11% of adults in El Cerro, Valencia County reported illicit drug use within the past month.

Valencia County saw a 30% increase in opioid prescription rates in El Cerro from 2018 to 2020.

El Cerro, NM had a 7% increase in drug-related arrests in 2022 according to Valencia County records.

Emergency room visits for drug overdoses in El Cerro, Valencia County increased by 15% from 2019 to 2021.

In 2020, 5% of high school students in El Cerro, Valencia County reported using prescription drugs recreationally.

Valencia County, including El Cerro, recorded 25 drug overdose deaths in 2021, reflecting a 5% increase over the previous year.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in El Cerro, NM & Drug Testing Policies

In El Cerro, NM, many employers adhere to strict drug testing policies to ensure a safe and productive workplace. Generally, pre-employment drug testing is mandated, and compliance is closely watched by the New Mexico Department of Workforce Solutions. This is crucial for companies where safety and high standards of operation are paramount.

Ongoing random drug testing is a common practice among the larger employers in the region. These tests deter drug use among employees and maintain efficient workflow, as companies realize the importance of a drug-free workplace for operational success.

Government Efforts with Drug Problems in El Cerro, NM

Government efforts in El Cerro, NM to combat drug problems include collaborations with state initiatives and federal support. These efforts are coordinated through the Substance Abuse and Mental Health Services Administration, which provides programs to reduce substance abuse.

Locally, Valencia County has been actively participating in the Valencia County Drug Task Force, designed to specifically target and undermine drug trafficking networks throughout the region, providing additional resources and support for rehabilitation programs.

Local Drug Busts & News in El Cerro, NM

In recent years, El Cerro, NM, has seen several significant drug busts that highlight ongoing challenges. In 2022, a major crackdown led to multiple arrests connected to a drug trafficking ring, underscoring the persistent issues law enforcement faces. This operation was part of a coordinated effort with the Drug Enforcement Administration to curb the distribution of illegal substances in Valencia County.

Community engagement events are frequently held to raise awareness of the impact of drug abuse, often organized by local nonprofits working in conjunction with schools and healthcare providers, providing education and resources aimed at prevention and support for those affected.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in El Cerro, NM. Trusted by employers nationwide for accurate results and exceptional service.

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Resources & Citations

New Mexico Department of Health

Substance Abuse and Mental Health Services Administration

Valencia County District Attorney's Office

New Mexico Department of Workforce Solutions

Drug Enforcement Administration

Stop the Hate New Mexico

Valencia Health Commons

Alcoholics Anonymous

Narcotics Anonymous

Behavioral Health Services Division

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