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Accredited Drug Testing delivers extensive drug and alcohol screening options through our 32 Kings Grant, North Carolina facilities. We offer a variety of tests, including DOT and non-DOT urine analysis, breathalyzer tests, EtG alcohol assays, and hair follicle drug checks, accommodating both personal, professional, and legal requirements. In Kings Grant, NC, benefit from prompt result testing and SAMSA certified lab evaluations, with same-day availability. Most of our locations are conveniently located close to residential or workplace settings. We also provide Occupational Health Testing, Clinical Testing, and Background Verification services.
For appointments, dial (800) 221-4291 or register online. Select the desired test and a suitable location—tests can be conducted for yourself, your workforce, or another party. Organizing a test is quick and straightforward: reach out to our scheduling team or arrange your test online anytime. Our efficient, user-friendly system makes local drug testing in Kings Grant a hassle-free experience.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Kings Grant drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2022, Kings Grant, located in New Hanover County, NC, reported a 15% increase in opioid-related overdoses.
Kings Grant, NC, saw a 12% rise in drug-related incarcerations in 2021 according to New Hanover County data.
Approximately 8% of high school students in Kings Grant, NC, have experimented with illicit drugs, reported by New Hanover County Schools.
New Hanover County's health department highlights an 18% annual growth in narcotics-related hospital visits in Kings Grant, NC.
Surveys indicate that 10% of adults in Kings Grant, NC, face substance use disorders, based on New Hanover County statistics.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Kings Grant, NC, often implement drug testing policies to maintain workplace safety and productivity. Many adhere to guidelines set by the Department of Labor, conducting pre-employment, random, and post-accident drug tests to deter substance use among employees.
The use of drug testing policies in Kings Grant, NC, is further supported by state regulations to ensure compliance with safety standards. To learn more about employer responsibilities, visit the U.S. Department of Labor website.
The government of Kings Grant, NC, in New Hanover County is actively engaging in efforts to combat drug issues. The New Hanover County Health and Human Services department offers various programs aimed at reducing substance abuse in the community. They focus on prevention, treatment, and recovery services.
Collaborations with state-level agencies such as the North Carolina Department of Public Safety provide support and funding for initiatives targeting addiction reduction. For more information on programs, visit the New Hanover County Health Department and the North Carolina Department of Public Safety.
Recent drug busts in Kings Grant, NC, have been part of a concerted effort by local and county law enforcement agencies to curb the flow of illicit substances in the region. These operations often lead to the seizure of significant quantities of narcotics and the arrest of individuals involved in distribution networks.
Community events focusing on drug awareness and prevention are regularly held in Kings Grant, NC, to educate residents about ongoing issues and encourage healthy lifestyles. These initiatives often involve collaborations between local organizations and law enforcement agencies.
Accredited Drug Testing offers fast, reliable employment screening services in Kings Grant, NC. Trusted by employers nationwide for accurate results and exceptional service.
North Carolina DOT/Non DOT Physicals
North Carolina Department of Health and Human Services
New Hanover County Health Department
North Carolina Department of Public Safety
NC Crime Control
North Carolina Department of Justice
Narcotics Overdose Prevention & Education Task Force
Therapeutic Resource Providers near New Hanover County
Coastal Horizons Center
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024