Drug Testing Locations - Lake Park, NC

Drug Testing in Lake Park, NC

Lake Park, North Carolina Statistics

In Lake Park, NC, Union County reported a 15% increase in opioid overdoses from 2018 to 2019.

Lake Park, NC, saw a 25% rise in drug-related arrests in Union County in 2020.

Union County, where Lake Park is located, documented 50 cases of heroin overdose in 2021.

In 2022, 20% of high school students in Union County, which includes Lake Park, admitted to trying marijuana.

Union County observed a 10% decrease in methamphetamine-related incidents in 2022.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Lake Park, NC & Drug Testing Policies

Employers in Lake Park, NC, are increasingly implementing stringent drug testing policies to maintain a drug-free workplace. Businesses often partner with third-party drug testing services to conduct pre-employment screening and random tests to deter substance abuse among employees.

The North Carolina Chamber of Commerce (NC Chamber) provides guidance to local businesses on establishing effective drug testing policies that comply with state and federal regulations. Many employers use these resources to craft policies that align with their company culture and legal standards.

Government Efforts with Drug Problems in Lake Park, NC

The local government in Lake Park, NC, along with Union County officials, have been actively working to combat drug problems. They have initiated various community outreach programs that focus on prevention and education, aiming to reduce substance abuse among the youth.

Collaboration with state agencies like the North Carolina Department of Health and Human Services (NCDHHS) has bolstered efforts through funding and access to resources for treatment and rehabilitation, emphasizing a multi-faceted approach.

Local Drug Busts & News in Lake Park, NC

Lake Park, NC, and the surrounding areas in Union County have witnessed several significant drug busts in recent years. These operations, often conducted in coordination with the Union County Sheriff's Office, have led to the confiscation of substantial quantities of illegal substances.

Recently, a joint task force operation in Union County resulted in the arrest of multiple individuals involved in a large-scale methamphetamine distribution network. This bust highlights the continued efforts of law enforcement to curb drug-related activities in the region.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Lake Park, NC. Trusted by employers nationwide for accurate results and exceptional service.

North Carolina DOT/Non DOT Physicals

North Carolina Vision Tests

North Carolina Audiograms

North Carolina Respirator Fit Tests

North Carolina Lift Tests

North Carolina Background Checks

Clinical Testing Services

TB Testing in NC

Diabetes Testing in NC

Infectious Disease Testing in NC

Sickle Cell Anemia Testing in NC

Women/Men's Health Testing in NC

Resources & Citations

NCDHHS

North Carolina Substance Abuse Advisory Council

North Carolina Prevention Services

National Council on Alcoholism and Drug Dependence - NC

North Carolina Harm Reduction Coalition

Partnership for Drug-Free North Carolina

North Carolina Medical Society

The Arc of North Carolina

Drug Testing Near Lake Park, NC

Monroe, NC

Providence, NC

Hillsdale, NC

Unionville, NC

Mint Hill, NC

Wesley Chapel, NC

Matthews, NC

Stallings, NC

Hemby Bridge, NC

Indian Trail, NC

Frequently Asked Questions

Customer Reviews