Drug Testing Locations - Phoenix, OR

Drug Testing in Phoenix, OR

Phoenix, Oregon Statistics

In 2022, Jackson County, home to Phoenix, OR, saw a 15% increase in drug-related arrests compared to the previous year.

The rate of opioid overdoses in Jackson County was reported at 9.3 per 100,000 people in 2021.

Jackson County reported a 12% decrease in cocaine-related incidents in 2021 as opposed to 2020.

Methamphetamine was involved in 54% of the drug violation cases in Jackson County in 2022.

In 2021, 24% of individuals admitted for substance abuse treatment in Jackson County were from the Phoenix area.

Prescription drug abuse in Jackson County saw a 7% decline from 2020 to 2021.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Phoenix, OR & Drug Testing Policies

Employers in Phoenix, OR, are increasingly adopting stringent drug testing policies to maintain a safe working environment. Companies often engage with local drug testing services to conduct pre-employment and random drug testing, ensuring compliance with workplace safety standards.

Resources such as OSHA's guidance and Department of Labor policies are often utilized by businesses to align with federal regulations. These policies not only help in mitigating risks associated with employee drug use but also in supporting employees who seek assistance for substance abuse issues.

Government Efforts with Drug Problems in Phoenix, OR

The city of Phoenix, OR, is actively involved in addressing drug abuse through collaboration with Jackson County's District Attorney's Office. Their initiatives include community outreach and education programs that aim to reduce substance misuse and connect individuals with resources.

At the state level, Oregon has implemented measures to combat drug abuse, including Oregon Health Authority's programs that focus on prevention and treatment. Additionally, efforts to increase access to rehabilitation services and medical-assisted treatment are ongoing at both local and state levels.

Local Drug Busts & News in Phoenix, OR

Law enforcement agencies in Phoenix, OR, regularly conduct drug busts to curb illegal drug trafficking. These operations are often a collaborative effort involving local police and agencies like the DEA, resulting in significant drug seizures and arrests.

Community involvement in drug-related events is encouraged by local organizations that host awareness campaigns and educational seminars about the dangers of drug abuse. These events aim to reduce stigma and promote community mobilization against drug misuse.

Occupational Health Services

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Resources & Citations

Addiction Center - Oregon Rehabs

Emerge Reentry

Rogue Retreat

Narconon Oregon

Mercy Flights

Phoenix Counseling Center

Oregon Health Authority

Sober Guild

Jacobs Hope

Safe Place: The Encompass Connection

Drug Testing Near Phoenix, OR

Sams Valley, OR

Gold Hill, OR

Lake Creek, OR

Eagle Point, OR

White City, OR

Ruch, OR

Southwest Jackson, OR

Central Point, OR

Jacksonville, OR

Ashland, OR

Medford, OR

Talent, OR

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