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Accredited Drug Testing delivers thorough drug and alcohol tests at our 34 centers in the Penn Hills, Pennsylvania region. We cater to both DOT and non-DOT testing requirements including urine drug tests, breath and EtG alcohol screenings, as well as hair drug tests for individuals, employers, and legal purposes. Penn Hills, PA offers quick result tests and SAMSA certified lab analyses, with same day service possible. Most Penn Hills drug test sites are conveniently close to residential and work sites. We also conduct Occupational Health Testing, Clinical Assessments, and Background Screenings.
Contact us at (800) 221-4291 or book online. Simply select your desired test and a nearby center—testing can be arranged for yourself, employees, or any other individual. Scheduling is both quick and straightforward, whether you call our scheduling team or choose to plan your test online anytime. Our efficient and intuitive procedure ensures setting up drug testing near Penn Hills is done with ease.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Penn Hills drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Penn Hills, located in Allegheny County, reported a 30% rise in opioid-related deaths in 2022.
In 2022, Penn Hills experienced a 15% increase in drug-related arrests compared to the previous year.
Allegheny County Health Department recorded a significant surge in fentanyl use in Penn Hills in 2021.
Penn Hills witnessed a 20% rise in heroin overdose cases in the past year, according to local law enforcement.
A community survey in Penn Hills indicated that 25% of respondents knew someone affected by substance abuse.
Emergency departments in Allegheny County reported an uptick in drug overdose calls from Penn Hills in late 2022.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Penn Hills adhere to stringent drug testing policies to ensure workplace safety and productivity. These policies are in alignment with federal regulations outlined by the U.S. Department of Labor, which you can find on their official website.
Local businesses often collaborate with health professionals to conduct regular drug awareness sessions to prevent workplace substance abuse. Such initiatives are supported by guidelines from the Occupational Safety and Health Administration (OSHA), helping create a safer work environment.
The government of Penn Hills, alongside Allegheny County, has been actively increasing funding for substance abuse programs. This includes outreach initiatives and educational campaigns aimed at reducing drug addiction. More information can be found on the Allegheny County official website.
State-level interventions, supported by Pennsylvania's Department of Drug and Alcohol Programs, have introduced stricter regulations and more accessible rehabilitation services to tackle the growing drug issues in Penn Hills. For more details, visit the Pennsylvania Department of Drug and Alcohol Programs.
In recent months, law enforcement agencies in Penn Hills, PA, have intensified their efforts to curb the illegal drug trade. A significant bust involved several coordinated raids targeting suspected narcotics distributors. This operation led to the arrest of multiple individuals and the confiscation of substantial quantities of illegal substances, including heroin and fentanyl, along with firearms and cash, highlighting the severity of drug issues in the area.
The increased presence of law enforcement in Penn Hills reflects rising community concerns over drug-related activities. Residents have actively engaged in dialogues with local authorities, emphasizing the need for continuous vigilance. The growing collaboration between the community and law enforcement has resulted in several tips that have been instrumental in recent drug operations, fostering a safer environment.
Drug education programs in Penn Hills schools have been bolstered in response to these events, focusing on prevention and awareness among youth. Various initiatives aim to equip students with the necessary tools to resist peer pressure and make informed decisions. Community leaders are advocating for more comprehensive approaches that combine education with accessible support services to effectively address substance abuse challenges.
Accredited Drug Testing offers fast, reliable employment screening services in Penn Hills, PA. Trusted by employers nationwide for accurate results and exceptional service.
Pennsylvania DOT/Non DOT Physicals
Pennsylvania Department of Health
Allegheny County Health Department
Commonwealth of Pennsylvania
PA Department of Drug & Alcohol Programs
Substance Abuse and Mental Health Services Administration
Centers for Disease Control and Prevention
Recovery.org
The Council of Southeast Pennsylvania
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024