Drug Testing Locations - Brookdale, SC

Drug Testing in Brookdale, SC

Brookdale, South Carolina Statistics

In Brookdale, SC, Orangeburg County, the overdose death rate increased by 15% in 2022 compared to the previous year.

The opioid prescription rate in Orangeburg County was 67.4 per 100 residents in 2021.

In 2021, 35% of drug-related arrests in Brookdale, SC were linked to methamphetamine.

The Narcan administration by first responders rose by 22% in Orangeburg County in 2022.

A survey in Orangeburg County reported that 12% of high school students tried illicit drugs in 2021.

Brookdale, SC, saw a 10% increase in drug rehabilitation admissions in the year 2022.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Employers in Brookdale, SC & Drug Testing Policies

Employers in Brookdale, SC, are actively implementing drug testing policies to ensure a safe and productive workplace. Many companies follow guidelines established by the U.S. Department of Labor, promoting a drug-free work environment.

Pre-employment screening and random drug tests have become common practices, reflecting a community-wide effort to reduce substance abuse. Employers often work with local clinics for efficient and reliable drug testing services, fostering a responsible workforce culture.

Government Efforts with Drug Problems in Brookdale, SC

The government of Brookdale, SC, in Orangeburg County, has initiated various efforts to combat drug abuse. Local authorities work in collaboration with state agencies, such as the South Carolina Department of Alcohol and Other Drug Abuse Services, to implement rehabilitation and awareness programs.

Additionally, the county has received support from federal grants to enhance law enforcement capabilities and community outreach efforts. Partnerships with the Substance Abuse and Mental Health Services Administration (SAMHSA) have facilitated better access to treatment options.

Local Drug Busts & News in Brookdale, SC

Brookdale, SC, has seen several significant drug busts contributing to local law enforcement efforts. In a recent operation, Orangeburg County law enforcement seized a substantial amount of narcotics, underscoring the ongoing battle against drug trafficking.

Drug enforcement agencies in the area frequently collaborate for joint operations, aiming to dismantle networks and reduce crime. Such events raise community awareness and highlight the importance of tackling drug-related issues at the local level.

Occupational Health Services

Accredited Drug Testing offers fast, reliable employment screening services in Brookdale, SC. Trusted by employers nationwide for accurate results and exceptional service.

South Carolina DOT/Non DOT Physicals

South Carolina Vision Tests

South Carolina Audiograms

South Carolina Respirator Fit Tests

South Carolina Lift Tests

South Carolina Background Checks

Clinical Testing Services

TB Testing in SC

Diabetes Testing in SC

Infectious Disease Testing in SC

Sickle Cell Anemia Testing in SC

Women/Men's Health Testing in SC

Resources & Citations

SC DAODAS

Just Plain Killers

SC Prevention

Impact Futures Coalition

SAMHSA

CARF International

Nar-Anon Family Groups

SC Al-Anon Family Groups

Orangeburg County

New Hope Treatment Centers

Drug Testing Near Brookdale, SC

Highland, SC

Wade Hampton, SC

Fairmont Mills, SC

Gramling, SC

Inman, SC

Reidville, SC

Inman Mills, SC

Taylors, SC

Startex, SC

Wellford, SC

Lyman, SC

Greer, SC

Duncan, SC

Frequently Asked Questions

Customer Reviews