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At our 2 testing centers in Wounded Knee, SD, Accredited Drug Testing delivers an extensive range of drug and alcohol screening services. We offer both DOT and non-DOT urine drug tests, breath alcohol tests, EtG alcohol assessments, and hair drug screenings, tailored for individuals, companies, and legal requirements. Our quick results testing and SAMSA-endorsed lab evaluations in Wounded Knee, SD, ensure results are prompt, with most centers being just minutes from your residence or workplace. We also provide Occupational Health Services, Clinical Analysis, and Background Verification.
Reach out by calling (800) 221-4291 or register online. Simply pick your test and choose a nearby location. Available for personal, employee, or third-party testing, scheduling is effortless—either via our scheduling department or online 24/7. Our convenient and efficient platform simplifies drug test arrangements near Wounded Knee seamlessly.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Wounded Knee drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Wounded Knee, Shannon County, over 10% of high school students have reported using illicit drugs.
Wounded Knee, Shannon County, has seen a 15% increase in prescription drug misuse among adults since 2018.
Opioid-related overdoses in Wounded Knee, Shannon County, increased by 12% in the last year.
More than 20% of residents in Wounded Knee, Shannon County, seek substance abuse treatment annually.
Shannon County, which includes Wounded Knee, reports a higher incidence of methamphetamine use compared to the state average.
Wounded Knee, in Shannon County, experiences a significant number of arrests related to drug possession annually.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
The employers in Wounded Knee, SD, are increasingly adopting strict drug testing policies to ensure a safe workplace. These policies often require pre-employment drug screening and random testing throughout the tenure of employment. Employers also provide resources for employees seeking help for substance abuse.
Collaboration with state agencies, such as the South Dakota Department of Labor and Regulation, helps employers implement comprehensive drug policies. This aids in reducing workplace-related drug issues and promoting a healthier environment.
Employee assistance programs are promoted among businesses in Wounded Knee to support workers struggling with addiction. These programs offer counseling and referrals to local treatment facilities, reflecting employers' commitment to employee well-being.
The government has intensified efforts to address drug problems in Wounded Knee, SD. Local initiatives include partnering with tribal authorities to enhance prevention programs and community outreach. Resources are being allocated to improve rehabilitation facilities and provide education on substance abuse.
State and federal agencies, such as the SAMHSA, collaborate to fund programs aimed at reducing drug supply and demand. The integration of technology-driven solutions for monitoring and reporting is also being explored to combat the ongoing crisis.
Wounded Knee, SD, has witnessed several significant drug busts in recent years. These events have targeted illegal drug distribution networks operating in Shannon County. Law enforcement agencies continue to collaborate to tackle the growing issue of methamphetamine and opioid distribution in the area.
Community events are occasionally organized to raise awareness of the drug problem and educate residents on the signs of drug abuse. These events offer a platform for residents to engage with local authorities and discuss strategies to prevent drug-related activities in Wounded Knee.
Such operations have often led to large-scale arrests, significantly impacting local drug circulation. These efforts are a testament to the active involvement of law enforcement in curbing the drug menace, enhancing community safety.
Accredited Drug Testing offers fast, reliable employment screening services in Wounded Knee, SD. Trusted by employers nationwide for accurate results and exceptional service.
South Dakota DOT/Non DOT Physicals
South Dakota State Government
Helpline Center 211
South Dakota Department of Health
South Dakota Behavioral Health
South Dakota Prevention Coalition
South Dakota Network Against Family Violence and Sexual Assault
Edwina Addiction Services
Great Plains Tribal Health
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024