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In the Alpha region of Tennessee, Accredited Drug Testing provides extensive drug and alcohol assessments at 35 local facilities. We conduct both DOT and non-DOT urine analyses, breathalyzer evaluations, EtG alcohol screenings, and hair drug tests for private purposes, business needs, and legal requirements. Our Alpha centers deliver quick result testing and SAMSA-certified lab assessments with same-day service, conveniently located near your home or workplace. Other offerings include Occupational Health Evaluations, Clinical Tests, and Background Screenings.
Dial (800) 221-4291 or visit our website to get started. Choose your preferred test type and a nearby center—testing options are open for personal use, employees, or third parties. With our Fast and Easy scheduling, connect with our scheduling team or book online anytime. Our efficient system enables simple arrangement of drug testing close to Alpha.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Alpha drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2022, Alpha, TN, located in Hamblen County, saw a 15% increase in opioid-related emergency room visits.
Drug-related arrests in Alpha, TN, Hamblen County, have risen by 10% over the past year.
Hamblen County, including Alpha, TN, reported a 25% increase in drug abuse treatment admissions in 2022.
The rate of drug overdose deaths in Alpha, TN, Hamblen County, was 20% higher in 2022 compared to the national average.
In 2021, Alpha, TN, Hamblen County, accounted for 5% of the state's total drug-related offenses.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Alpha, TN, such as those in manufacturing and healthcare, have implemented strict drug testing policies. These measures are in place to ensure workplace safety and productivity. For instance, employers often require pre-employment and random drug screenings. The Occupational Safety and Health Administration, provides guidelines for maintaining a drug-free workplace.
Some companies collaborate with local clinics for drug testing, ensuring processes are efficient. They also provide employee assistance programs (EAPs) supporting substance abuse counseling and rehabilitation. More information on these programs can be found through the U.S. Department of Labor.
The government in Alpha, TN, within Hamblen County, has launched several initiatives to combat drug abuse. These include community outreach programs, increased law enforcement training, and funding for mental health services. For more information, visit the Tennessee Department of Mental Health and Substance Abuse Services.
The introduction of drug courts in Hamblen County has been one of the several successful approaches used by Alpha, TN, to address drug problems. These courts focus on rehabilitation over punishment for non-violent drug offenders, offering an alternative to incarceration. More details are available on the Tennessee State Courts website.
In recent months, Alpha, TN has witnessed a surge in drug-related activities, prompting increased law enforcement. Several coordinated drug busts have taken place throughout the town, targeting key figures in the local drug trade. These operations have led to significant seizures of narcotics, along with arrests that are expected to disrupt the supply chain considerably.
A notable incident involved a large-scale bust at a warehouse on the outskirts of Alpha. The operation uncovered substantial quantities of illicit substances, including methamphetamine and opioids, stored and ready for distribution. Authorities credit diligent investigative work for the success of this raid, which marks a substantial victory against drug trafficking networks.
Community efforts in Alpha have also contributed to addressing the drug issue. Local organizations are stepping up to offer rehabilitation and support services to individuals affected by substance abuse. Educational programs in schools aim to increase awareness and prevent drug use among the youth, promoting healthier lifestyle choices and highlighting the dangers of drug addiction.
Accredited Drug Testing offers fast, reliable employment screening services in Alpha, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Tennessee Department of Mental Health and Substance Abuse Services
Tennessee Mental Health Consumers' Association
National Council on Alcoholism and Drug Dependence of East Tennessee
National Alliance on Mental Illness Tennessee
Tennessee Association of Alcohol, Drug & Other Addiction Services
Foundation for Recovery
Recovery Within Reach Tennessee
Commission on Accreditation of Rehabilitation Facilities
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024