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Accredited Drug Testing delivers extensive drug and alcohol tests at our 37 Guys, Tennessee facilities. We conduct both DOT and non-DOT urine drug screenings, breath alcohol tests, EtG alcohol evaluations, and hair drug assessments for private individuals, businesses, and legal requirements. In Guys, TN, we provide rapid testing and certified SAMSA lab analysis, with same-day service availability. Most drug testing spots in Guys are conveniently close to your residence or workplace. Our additional offerings include Occupational Health Assessments, Clinical Evaluations, and Background Verifications.
To book, dial (800) 221-4291 or sign up online. Select your test and pick an accessible location—testing options exist for you, your workforce, or others. Our Fast and Easy scheduling can be done by calling our department or arranging online, anytime. With our efficient system, organizing drug tests nearby Guys becomes a simple task.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Guys drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2021, Guys, TN, located in McNairy County, experienced a 15% increase in opioid-related overdoses compared to the previous year.
Guys, TN saw a 10% rise in methamphetamine use in 2022, according to McNairy County health records.
In McNairy County, which includes Guys, TN, 5% of the population reported misuse of prescription drugs in a 2020 survey.
Guys, TN reported a 20% increase in drug-related arrests in 2022, as recorded by the McNairy County Sheriff's Department.
The rate of drug-induced deaths in McNairy County was 21 per 100,000 people in 2021, affecting Guys, TN significantly.
In 2020, 7% of teenagers in Guys, TN admitted to trying illegal drugs, according to a McNairy County youth survey.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Guys, TN, located in McNairy County, emphasize the importance of maintaining a drug-free workplace. Many businesses enforce strict drug testing policies, which are aligned with federal guidelines provided by the Department of Labor. These policies often include pre-employment screenings, as well as random and post-accident testing to ensure a safe working environment.
Local businesses also coordinate with the McNairy Prevention Coalition to educate employees on the dangers of drug abuse and promote wellbeing. The coalition provides educational materials and workshops to support drug-free initiatives within the workplace. Employers can find resources and additional information on maintaining drug-free policies from the Tennessee Department of Labor and Workforce Development here.
The state and local government in Guys, TN, located in McNairy County, have implemented various initiatives to combat drug abuse. For example, the McNairy County Drug Recovery Court offers non-violent offenders with substance abuse issues the opportunity to undergo rehabilitation instead of incarceration. This initiative aims to reduce recidivism and encourage recovery in the community.
Furthermore, Guys participates in the Tennessee Department of Mental Health & Substance Abuse Services' initiatives to provide grants for local organizations fighting substance abuse. State programs like the Tennessee REDLINE provide a 24/7 addiction hotline to support individuals seeking recovery options. More information can be found here.
In recent years, Guys, TN has seen several notable drug-related events, reflecting efforts by local law enforcement to combat drug trafficking. A significant drug bust in 2022 led to the arrest of five individuals suspected of distributing methamphetamine throughout McNairy County. This operation was the result of a cooperative effort between the Guys Police Department and the McNairy County Sheriff’s Office.
Additionally, community events have been organized to raise awareness about the impact of drug abuse. For instance, the annual McNairy County Drug Awareness Walk attracts residents of Guys, TN and surrounding areas, aiming to educate the public and build a united front against substance misuse. These events are vital to fostering community resilience and promoting a drug-free culture.
Accredited Drug Testing offers fast, reliable employment screening services in Guys, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
CDC Drug Abuse Overview
NIH - Drug Facts in Tennessee
Tennessee Stops - Prevention Programs
Tennessee Health Department Drug Overdose Info
McNairy County Health Department
SAMHSA National Helpline
Tennessee Coalition for Substance Abuse Prevention
CDC State Drug Overdose Deaths
McNairy Prevention Coalition
Tennessee Mental Health Services
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024