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Accredited Drug Testing provides thorough alcohol and drug test services at 40 locations around Holston Valley, Tennessee. Our offerings include both DOT and non-DOT urine tests, breathalyzer checks, EtG alcohol screenings, and hair drug assessments, catering to individuals, businesses, and legal requirements. We ensure swift results and SAMSA-certified lab analyses, with most testing sites conveniently situated near your residence or workplace in Holston Valley, TN. Furthermore, we provide Occupational Health Assessments, Clinical Screenings, and Background Verification services.
To schedule, dial (800) 221-4291 or register digitally. Pick your test and the nearest site—testing options are offered for personal, employee, or third-party use. With our efficient process, organizing a test is simple and straightforward. Contact our scheduling team or book online at any hour. Our hassle-free system facilitates arranging drug tests in Holston Valley with ease.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Holston Valley drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Holston Valley, Sullivan County reported a 12% increase in drug overdose deaths from 2019 to 2020.
Sullivan County, including Holston Valley, had 175 opioid-related emergency room visits per 100,000 people in 2020.
In 2021, over 70% of drug-related arrests in Holston Valley, located in Sullivan County, involved opioids.
Holston Valley in Sullivan County saw a 20% increase in drug-related criminal cases in 2020.
Sullivan County, where Holston Valley is situated, ranked 8th in Tennessee for highest rate of drug abuse in 2021.
Drug possession offenses in Holston Valley, Sullivan County, increased by 15% from 2019 to 2021.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Holston Valley, situated in Sullivan County, are increasingly adopting stringent drug testing policies to maintain a safe workplace. Many businesses conduct pre-employment, random, and post-accident drug tests ensuring compliance with regulations. Visit the Occupational Safety and Health Administration (OSHA) for more workplace safety guidelines.
The emphasis on drug testing helps employers in Sullivan County not only in maintaining health standards but also in reducing insurance costs and increasing overall employee productivity, aligning with the broader state guidelines set by the Tennessee Department of Labor and Workforce Development.
The government of Holston Valley, within Sullivan County, has implemented several initiatives to combat drug abuse. Through the Tennessee Department of Health, strategies focus on education, prevention, and treatment services, enhancing community resilience against drug threats.
At the state level, the Tennessee Bureau of Investigation supports local police in investigating drug-related crimes, providing data and resources to proactively address the issue in a concerted effort to reduce substance abuse in communities across Sullivan County.
In recent years, Holston Valley, within Sullivan County, has seen a rise in notable drug busts as local law enforcement steps up efforts to curtail drug trafficking. For instance, a significant operation in 2022 led to the seizure of substantial amounts of illicit substances, reflecting the ongoing battle against drug distribution networks.
These events highlight the commitment of local and state authorities, such as the Tennessee Bureau of Investigation, towards aggressive action against illegal drug activities, aiming to safeguard the community and deter future offenses in and around the Holston Valley area.
Accredited Drug Testing offers fast, reliable employment screening services in Holston Valley, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Tennessee Department of Mental Health & Substance Abuse Services
Haven of Rest
Care Addiction Rehabilitation
Metro Drug Coalition
Vista Recovery
Frontier Health
TN Department of Human Services
Sullivan County Health Department
Substance Abuse and Mental Health Services Administration (SAMHSA)
Tennessee Recovery and Emergency Preparedness
Quickly find trusted local drug testing centers in Holston Valley, TN — fast, convenient, and reliable every time!
Quickly find a local DOT drug testing center in Holston Valley, TN — fast, reliable, convenient nationwide service!
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024