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At our McKenzie, Tennessee facilities, Accredited Drug Testing offers a wide range of drug and alcohol assessments through 34 local centers. Suitable for both DOT and non-DOT purposes, we conduct urine drug screenings, breath alcohol, EtG, and hair follicle tests, addressing the needs of individuals, businesses, and legal entities. Offering rapid response tests and SAMSA lab-certified analyses, many of our McKenzie services can be accessed the same day, with locations close to your work or residence. We also provide Occupational Health, Clinical Testing, and Background Checks.
Reach us at (800) 221-4291 or register via our website. Choose your required test and the nearest facility—options are available for personal use, employee evaluations, or others. Organizing a test is swift and straightforward; contact our team or book your appointment online around the clock. Our process is designed for convenience, enabling seamless arrangement of drug screening within Mckenzie.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Mckenzie drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2020, Carroll County, which includes McKenzie, reported over 90 drug-related arrests.
Carroll County saw a 15% increase in opioid-related overdoses in 2021.
Methamphetamine is reported as the most common drug issue in McKenzie, TN.
Local reports from 2022 indicate that 12% of drug-related hospital admissions in McKenzie involved heroin.
In 2021, McKenzie, located in Carroll County, participated in a state-wide drug take-back program collecting over 200 pounds of unused medications.
A 2022 survey showed that 8% of high school students in McKenzie admitted to trying illegal drugs.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in McKenzie, TN, value workplace safety, which includes maintaining a drug-free environment. Many local businesses adhere to guidelines stipulated by the Tennessee Drug-Free Workplace Program. This program encourages employers to establish drug-free policies and conduct regular drug screenings.
Larger employers in McKenzie, such as healthcare facilities and manufacturing plants, implement strict drug testing policies to ensure compliance with industry regulations. They typically conduct pre-employment, random, and post-accident drug tests to deter substance abuse among employees.
Additionally, McKenzie's businesses partner with local agencies to run educational workshops for employees, focusing on the effects of substance abuse. Encouraging a supportive environment for employees struggling with addiction reflects the community's commitment to tackling this issue comprehensively.
The government has been proactive in tackling drug problems in McKenzie, TN, through various initiatives. Local law enforcement in Carroll County, which includes McKenzie, collaborates with state and federal agencies to conduct regular drug busts and preventive programs. The town has benefited from support from the Tennessee Department of Mental Health and Substance Abuse Services, providing resources for addiction recovery and prevention education.
Moreover, McKenzie officials work closely with city administration and the district's healthcare providers to implement effective substance use prevention strategies. The hosting of frequent drug take-back events aims to reduce the availability of prescription drugs contributing to substance abuse.
Local law enforcement in McKenzie, TN, has successfully conducted several notable drug busts in recent years. In 2022, a coordinated effort resulted in the seizure of significant quantities of methamphetamine and opioids, leading to multiple arrests. This operation was a part of a larger initiative within Carroll County to dismantle drug trafficking networks.
Community events such as McKenzie's annual drug awareness rallies aim to educate residents on the dangers of drug abuse. At these events, local health providers and law enforcement agencies provide resources and tips for prevention, underscoring the community's proactive approach to combating substance abuse.
The town frequently collaborates with local schools to host seminars aimed at middle and high school students, highlighting the importance of making informed decisions and avoiding drugs. These initiatives play a crucial role in community-level interventions against drug abuse.
Accredited Drug Testing offers fast, reliable employment screening services in Mckenzie, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Tennessee Substance Abuse Services
Office of Substance Abuse Services
Drug-Free Tennessee
Tennessee Association of Alcohol, Drug & other Addiction Services
Recovery Within Reach
Cumberland Heights
Tennessee Suicide Prevention Network
Hope for Tennessee
McKenzie Police Department
Carroll County Health Department
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024