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Accredited Drug Testing delivers extensive drug and alcohol testing solutions at 40 locations in the Poplar Top, Tennessee region. Our services include DOT and non-DOT urine drug screenings, breath alcohol assessments, EtG alcohol evaluations, and hair drug analyses, suitable for personal, corporate, and legal purposes. In Poplar Top, TN, we offer quick turnaround tests and SAMSA certified lab analysis. Same-day service is an option, with most testing sites conveniently close to your residence or workplace. We also conduct Occupational Health Testing, Clinical Testing, and Background Checks.
Contact us at (800) 221-4291 or sign up online. Pick your desired test and select a location nearby—testing is open for you, your employees, or others. Scheduling is simple and efficient; call our scheduling team or book your test online at any time. Our efficient, user-friendly system ensures you can organize drug testing in the Poplar Top area with minimal effort.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Poplar Top drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Poplar Top, Tipton County, reported a 25% increase in drug-related offenses in 2022.
In Poplar Top, Tipton County, opioid prescriptions dropped by 15% as of the last recorded data.
The number of methamphetamine-related arrests in Poplar Top, TN, rose by 10% over the past year.
Poplar Top, Tipton County, saw a 5% decrease in drug overdose deaths in 2023 compared to 2022.
Tipton County's needle exchange programs have helped reduce HIV transmission rates by 8% in Poplar Top.
Poplar Top, TN, reported a 30% increase in first-time drug offense cases in 2023.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Poplar Top, TN, adhere to both state and federal guidelines for workplace drug testing to ensure a safe and productive environment. Regular drug screening policies are common, especially in sectors with safety-sensitive positions.
Tennessee's Drug-Free Workplace Program, as outlined by the Tennessee Department of Labor and Workforce Development, provides a framework to help businesses prevent drug abuse. Many employers in Poplar Top have adopted these guidelines.
Furthermore, local businesses engage in educational initiatives, raising awareness about the risks of drug misuse and offering support services for employees struggling with addiction issues. This comprehensive approach helps maintain a healthier workplace environment.
The government in Poplar Top, TN, has implemented a series of initiatives aimed at tackling the ongoing drug problem. Efforts include enhanced access to treatment programs and increased funding for community outreach. Statewide programs such as the Tennessee Department of Health's initiatives also play a crucial role.
Collaboration with federal agencies, such as the DEA, has strengthened law enforcement efforts on the ground in Tipton County. Grants from the Department of Health and Human Services have additionally supported local mental health and addiction services, improving resources available to those in need.
Recent local drug busts in Poplar Top, TN, have highlighted the ongoing battle against illegal drug trafficking in Tipton County. Law enforcement's coordinated sting operations have led to several high-profile arrests over the past year.
One notable incident involved the seizure of methamphetamine and firearms, showcasing the collaboration between local police and federal agencies. These ongoing efforts have been crucial in curtailing the supply of illegal substances in Poplar Top.
Community forums and events regularly organized by local advocacy groups aim to inform residents about the consequences of drug abuse, fostering community resilience and support networks for those affected by addiction.
Accredited Drug Testing offers fast, reliable employment screening services in Poplar Top, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
TN Department of Mental Health & Substance Abuse Services
TN Department of Health
Addiction Center - Tennessee
Cumberland Heights
Stepworks Recovery Centers
Renewal House
Harbor House
Tennessee Health and Counseling Services
Memphis Recovery Centers
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024