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Accredited Drug Testing delivers a full range of drug and alcohol assessments across 37 centers in Powell Valley, Tennessee. Our services encompass DOT and non-DOT urine exams, breath alcohol analyses, EtG alcohol checks, and hair drug examinations tailored for individual, business, or legal contexts. Efficient results and certified lab analyses are accessible, with several Powell Valley test sites conveniently located nearby. We also provide Occupational Health Testing, Clinical Testing, and Background Verification services.
Dial (800) 221-4291 or sign up online. Choose your suitable test and find a nearby center — available for personal use, employees, or others. Test booking is straightforward and quick—contact our scheduling team or arrange it online any time of day. Our process, streamlined for ease, ensures setting up drug tests in Powell Valley is hassle-free.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Powell Valley drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Powell Valley, located in Claiborne County, TN, has seen a 15% increase in drug-related arrests over the past year.
In Claiborne County, 22% of high school students reported having tried illicit drugs within the last 12 months.
Powell Valley emergency departments reported a 10% rise in opioid overdose cases last year.
Methamphetamine-related crimes accounted for 30% of all drug offenses in Claiborne County, including Powell Valley, in recent reports.
Prescription drug abuse in Powell Valley, TN, doubled over the past five years, according to Claiborne County health data.
The Powell Valley region of Claiborne County has the third-highest rate of fentanyl-related deaths in Tennessee.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Powell Valley, TN, have adopted strict drug testing policies to maintain a safe and productive work environment. Many businesses in Claiborne County conduct regular drug screenings as part of their employment procedures, ensuring compliance with state regulations.
These policies aim to prevent workplace accidents and foster a drug-free environment. Resources for workplace drug policy guidelines can be found on the Substance Abuse and Mental Health Services Administration (SAMHSA) website, providing tools and information for employers.
The government in Powell Valley, TN, is actively addressing drug abuse. Local authorities have implemented drug education programs and rehabilitation services to aid individuals struggling with addiction. Claiborne County has partnered with state agencies to provide resources for families affected by substance abuse.
For more information, residents can visit the Tennessee Department of Mental Health & Substance Abuse Services and Claiborne County Government websites. These platforms offer information on available programs and support services for individuals in need.
Local law enforcement in Powell Valley, TN, recently executed a significant drug bust, uncovering a substantial amount of illegal substances. Coordinated efforts between local police and the county sheriff's department led to the arrest of multiple individuals. This operation was part of a broader initiative to combat drug trafficking in rural areas, emphasizing the community's commitment to safety and legal compliance.
Community awareness and involvement have been crucial in addressing drug-related issues in Powell Valley. Recently, neighborhood watch programs have been instrumental in reporting suspicious activities, leading to several minor drug seizures. These grassroots efforts reflect the town's proactive stance in combating drug misuse and ensuring a secure environment for all residents.
The impact of drug-related events in Powell Valley extends beyond criminal activities, affecting social fabric and public health. Local organizations and health departments have launched educational campaigns to raise awareness about the dangers of drug abuse. These initiatives aim to prevent addiction and provide support for those seeking recovery, demonstrating a comprehensive approach to addressing the issue.
Accredited Drug Testing offers fast, reliable employment screening services in Powell Valley, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Tennessee Department of Mental Health & Substance Abuse Services
Tennessee Human Services - Substance Abuse
Tennessee Prevent Child Abuse
CDC Workplace Drug Testing
Tennessee Drug Free Youth
National Institute on Drug Abuse - Tennessee
Mental Health Association of East Tennessee
SAMHSA
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024