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Accredited Drug Testing provides extensive drug and alcohol assessment services through our 33 centers around Big Stone Gap, Virginia. Our offerings include DOT and non-DOT urine analysis, breathalyzer alcohol tests, EtG testing for alcohol, and hair follicle drug screenings tailored for personal, corporate, and legal purposes. Fast and precise screening is accessible with same-day results at Big Stone Gap, VA, and we mainly rely on SAMSA certified labs. Our centers are conveniently situated close to your home or business. We also conduct Occupational Health Assessments, Clinical Testing, and Background Verification.
Dial (800) 221-4291 or register via our website. It's as simple as choosing your test type and the closest center—testing solutions are available for individuals, staff, or third parties. Organizing a test only takes a moment; contact our scheduling team or manage your booking online anytime. Our efficient and intuitive system simplifies drug test arrangements near Big Stone Gap.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Big Stone Gap drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Big Stone Gap in Wise County reported a significant increase in opioid-related incidents over the past year, according to state health department data.
The Wise County Schools in Big Stone Gap saw a 25% rise in drug-related suspensions in 2022 compared to the previous year.
Local law enforcement in Big Stone Gap has recorded a 15% increase in methamphetamine seizures during the past two years.
According to a 2022 state survey, approximately 8% of Big Stone Gap high school students reported misusing prescription drugs.
In Wise County, drug overdoses accounted for 60% of emergency room visits in early 2023.
The Big Stone Gap Community Services Board reported serving over 300 individuals for substance abuse issues in 2022.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Big Stone Gap, VA, have adopted stringent drug testing policies aimed at maintaining workplace safety and productivity. Many local businesses follow guidelines set by the U.S. Department of Labor for workplace standards. Random drug testing and pre-employment screenings are common practices to deter substance abuse among employees.
In addition to abiding by state legal requirements, some businesses collaborate with external drug testing facilities to ensure compliance and accuracy. Policies often cover a range of substances, including opioids and amphetamines, reflecting the specific challenges the community faces. Through these measures, employers contribute to a broader effort of promoting health and safety, ultimately benefiting both the workforce and the Big Stone Gap community as a whole.
Efforts by the local government in Big Stone Gap, VA, have been pivotal in addressing the profound drug abuse issues plaguing the area. Collaborations with the Wise County Sheriff's Office and regional health departments focus on program implementations aimed at prevention and rehabilitation. Initiatives such as the county's Narcan distribution program have been crucial in minimizing fatal overdoses.
State and federal support enhance these efforts through both funding and resources. Programs facilitated by agencies like the Virginia Department of Behavioral Health and Developmental Services aim to provide educational workshops and community health services. This multifaceted approach seeks not only to curb current issues but also provide long-term solutions through increased awareness and support infrastructure.
Big Stone Gap has been the scene of several notable drug busts in recent years, underscoring the persistent battle against drug abuse. A substantial operation led by the Wise County Sheriff's Office in mid-2022 resulted in the arrest of multiple individuals and the confiscation of large quantities of methamphetamine and fentanyl.
Local community events, such as the annual drug awareness fairs, provide platforms for educational outreach and resources for people battling addiction. These events often involve participation from health professionals, including personnel from local hospitals and treatment centers, offering support for recovery processes. By addressing these challenges head-on, Big Stone Gap continues to strive for a community free from the grips of drug dependency.
Accredited Drug Testing offers fast, reliable employment screening services in Big Stone Gap, VA. Trusted by employers nationwide for accurate results and exceptional service.
Virginia Department of Behavioral Health and Developmental Services
Virginia Department of Health
Wise County Jobs and Family Services
Nar-Anon Family Groups
Substance Abuse and Mental Health Services Administration
Narcan
Yes I Can
The Rivers Recovery Center
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024