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Accredited Drug Testing provides extensive drug and alcohol testing offerings across our 20 testing facilities in Franklin, Pennsylvania. Our services include DOT and non-DOT urine drug screenings, breath alcohol assessments, EtG alcohol tests, and hair drug tests for personal, business, and legal purposes. In Franklin, PA, we deliver quick result testing along with SAMSA certified lab analysis, and same-day services can be arranged. Most Franklin locations are conveniently close to your residence or workplace. We also supply Occupational Health Testing, Clinical Testing, and Background Checks.
Dial (800) 221-4291 or register online at your convenience. Choose your desired test and pick a location nearby—testing can be scheduled for yourself, employees, or another individual. The process is Fast and Easy; contact our scheduling team or arrange your test online any time. Our efficient and intuitive system ensures you can schedule drug testing near Franklin without hassle.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Franklin drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2021, Venango County reported over 200 opioid-related overdose deaths.
Franklin, PA saw a 15% increase in drug possession arrests in 2022 compared to 2021.
Venango County emergency services responded to 350 drug-related calls in 2022.
In Franklin, PA, 60% of drug abuse cases involve individuals aged 25-34.
In 2022, Franklin experienced a rise in methamphetamine abuse cases by 22%.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Franklin, PA, are increasingly implementing stringent drug testing policies to ensure workplace safety. Many companies require pre-employment screenings and conduct random tests to deter substance abuse among employees.
The U.S. Department of Labor provides guidelines on maintaining a drug-free workplace, which many local businesses in Venango County adhere to, ensuring compliance and safety standards are met.
Drug testing policies are also perceived as positive measures by employees, providing a supportive environment that encourages those struggling with substance abuse to seek help without stigma, supported by resources such as the Reach Out Recovery.
Government efforts to address drug problems in Franklin, PA, are robust and multifaceted. Local initiatives, supported by the Pennsylvania Department of Drug and Alcohol Programs, focus on both prevention and rehabilitation through community outreach and education programs.
The city collaborates with the Substance Abuse and Mental Health Services Administration to access federal resources and training. Additionally, there are ongoing partnerships with law enforcement to curb drug trafficking and provide treatment alternatives for offenders.
Recent drug-related events in Franklin, PA, highlight the community's ongoing struggle with substance abuse. A significant drug bust in early 2023 resulted in multiple arrests and the seizure of illicit substances, showcasing the proactive measures taken by Venango County law enforcement.
The local police department, often collaborating on operations with the Drug Enforcement Administration, remains vigilant in its efforts to dismantle distribution networks active within the city. Such initiatives are part of a broader strategy to prevent drugs from devastating the community.
Community educational events are also regularly organized to raise awareness, aimed at fostering resilience and preventive behaviors among the city’s youth, reflecting Franklin's commitment to tackling substance abuse on multiple fronts.
Accredited Drug Testing offers fast, reliable employment screening services in Franklin, PA. Trusted by employers nationwide for accurate results and exceptional service.
Pennsylvania DOT/Non DOT Physicals
Pennsylvania Department of Drug and Alcohol Programs
U.S. Attorney's Office Western District of Pennsylvania
Pennsylvania Narcotics Anonymous
Psychology Today - Venango County Therapists
Reach Out Recovery
FindTreatment.gov
Drug Enforcement Administration
Get Help Now Pennsylvania
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This is by far the easiest way to get my lab work ordered and paid for. The phone calls are short and to the point. They don’t try to push extra sales on you and when I walk in to the clinic I simply show my donor pass and with in a matter of minutes I’m done. I will continue to use ADT in the future.
Jason Jackson - 7/19/2025
Everything was great, the staff was very polite. Thank you.
Olga Petrova - 9/19/2024
The visit here is always the best . The place is always really clean. The employees are super courteous, very polite, and professional. This is the only drug lab I like to go do my drug and alcohol test. I would like to tell them thank you so much for thier excellent performance and job
Eli Gonzalez - 1/4/2025