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Comprehensive drug and alcohol screening services by Accredited Drug Testing are accessible at 35 locations in and around Lost Hills, California. Our offerings include DOT and non-DOT urine drug tests, breath alcohol assessments, EtG alcohol exams, and hair follicle drug screening, catering to personal, employer, and legal requirements. Swift result options and SAMSA-certified lab analysis are available, with same-day services potentially just minutes away from your home or workplace in Lost Hills, CA. We also provide Occupational Health Testing, Clinical Assessments, and Background Checks.
To schedule, call (800) 221-4291 or register through our website. Choose a test and a local center—testing options are available whether for you, your workforce, or someone else. Setting up a test is Fast and Easy; reach out to our scheduling team or arrange your appointment any time, day or night, online. Our efficient and intuitive system facilitates easy drug testing arrangements near Lost Hills.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Lost Hills drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2022, Lost Hills, Kern County reported a 15% increase in drug-related arrests compared to the previous year.
Kern County's opioid overdose death rate in 2021 was 12.9 per 100,000 residents, affecting Lost Hills as part of the county data.
In 2021, 56% of drug abuse cases in Lost Hills involved methamphetamine, making it the most common drug detected.
Emergency calls related to drug overdoses in Lost Hills, Kern County, saw a rise of 22% in 2022.
In a 2022 survey, 8% of Lost Hills high school students admitted to recreational drug use within the past 30 days.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
In Lost Hills, CA, employers take drug testing policies seriously to ensure workplace safety. Many organizations adhere to guidelines set by the California Department of Industrial Relations. Employers conduct pre-employment drug screenings as a standard practice. For more on state regulations, visit the California Department of Industrial Relations.
Some companies in Lost Hills may also implement random drug tests as part of their ongoing safety measures. The goal is to maintain a drug-free work environment conducive to productivity and safety. More about these practices can be viewed on the Society for Human Resource Management website.
The government of Lost Hills, Kern County has implemented various initiatives to combat drug abuse. The Kern County Behavioral Health and Recovery Services offers comprehensive programs to tackle substance abuse issues. You can learn more about their services here.
The state of California has also launched the Safe and Active Communities Program to support communities like Lost Hills in reducing drug problems. More information about state efforts can be found here.
Law enforcement agencies in Lost Hills, Kern County, have actively conducted several drug busts in recent years, leading to significant seizures of illegal substances. For instance, a 2022 operation led to the confiscation of over 50 pounds of methamphetamine and the arrest of several individuals involved in drug trafficking.
The local community holds regular drug awareness events aimed at educating residents about the dangers of drug abuse. These events often feature speakers from the Kern County Sheriff's Office and other health professionals.
Accredited Drug Testing offers fast, reliable employment screening services in Lost Hills, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
Kern County Behavioral Health and Recovery Services
California Department of Public Health
Substance Abuse and Mental Health Services Administration
Kaiser Permanente Addiction Medicine
Nar-Anon Family Groups
Safe and Active Communities Program
California Consortium of Addiction Programs and Professionals
211 Kern County
Recovery International
Society for Human Resource Management
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024