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In Portola Valley, CA, we offer a wide range of drug and alcohol testing services through our 34 convenient testing centers. Our services cater to legal requirements, personal needs, and workplace compliance with both DOT and non-DOT urine tests, breath tests, EtG alcohol screens, and hair analysis. We guarantee quick response times, with rapid testing and certified laboratory analysis by SAMSA, as well as same-day services for most requests. Our facilities are usually just a short drive from where you work or reside. We additionally conduct Clinical and Occupational Health Tests, along with thorough Background Checks.
You can either call (800) 221-4291 or use our online registration for your testing needs. Just select the required test and the most convenient location for you—whether it be for personal use, employee requirements, or other circumstances. The process to book a test is straightforward and can be done anytime, day or night, over the phone or online. Arranging for testing in the Portola Valley area is now an easy task with our efficient system.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Portola Valley drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Portola Valley, located in San Mateo County, reports a rise in opioid-related incidents by 20% over the past three years.
Alcohol remains the most commonly abused substance in Portola Valley, San Mateo County, with over 50% of cases related to it.
Cannabis use among teens in Portola Valley, San Mateo County, has increased by 15% according to the latest surveys.
Portola Valley, San Mateo County, has seen a decrease in methamphetamine arrests by 10% compared to last year.
Prescription drug abuse in Portola Valley, San Mateo County, contributes to 30% of hospital admissions for substance abuse.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Portola Valley, CA are keenly aware of the impact that substance abuse can have on workplace productivity and safety. Many have therefore implemented comprehensive drug testing policies. These policies are often in alignment with the guidelines provided by the California Department of Industrial Relations.
Regular drug testing is conducted both pre-employment and randomly throughout the year to ensure a safe working environment. Employers typically follow state regulations and best practices for drug testing, as outlined by the U.S. Department of Labor, to maintain fairness and clarity. These measures help in fostering a drug-free workplace in Portola Valley and contribute to the well-being of the employees.
The government of Portola Valley, CA has implemented various strategies to combat drug problems in the area. These include partnerships with local San Mateo County Health officials and the deployment of community-wide drug prevention programs. Additionally, the town engages in awareness campaigns targeting both youth and adults to reduce substance abuse.
The San Mateo County Sheriff’s Office is actively involved in efforts to curb drug activities through increased patrols and community outreach programs. State-level initiatives, supported by California's Department of Health Care Services, aim to provide treatment and rehabilitation resources to those in need, facilitating recovery and preventing relapses.
Recent months have seen few notable drug-related events in Portola Valley, CA. However, in past years, cooperation between the San Mateo County Sheriff's Office and local police led to a significant drug bust that disrupted a major methamphetamine distribution ring in the area.
Community drug take-back events are periodically organized in Portola Valley to safely dispose of unused prescription drugs. These initiatives, coordinated with local agencies, aim to reduce the risk of misuse and environmental harm due to improper disposal.
Accredited Drug Testing offers fast, reliable employment screening services in Portola Valley, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
San Mateo County Health
San Mateo County Sheriff's Office
San Francisco City Clinic
Recovery.org
Nar-Anon Family Groups
Ulysses Press
HealthRIGHT 360
California Drug Helpline
Santa Cruz County Health Services
The Caduceus Club
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024