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Accredited Drug Testing provides a wide array of drug and alcohol screening solutions at our 39 testing locations in and around Sierra Madre, CA. We offer both DOT and non-DOT urine drug tests, breath alcohol tests, EtG alcohol testing, and hair drug analyses for individuals, employers, and legal entities. Benefit from immediate results testing and SAMSA certified laboratory analysis; same-day services are accessible, with most centers just a short distance from your residence or office. Additionally, we provide Occupational Health Testing, Clinical Testing, and Background Checks in Sierra Madre, CA.
Reach us at (800) 221-4291 or register online. Pick your test and a nearby testing location—available for yourself, employees, or another person. Scheduling is quick and hassle-free; contact our scheduling team or book your test online, anytime. Our efficient and intuitive process simplifies arranging drug tests near Sierra Madre.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Sierra Madre drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2020, Sierra Madre, CA had a reported 5% increase in drug-related emergency calls, indicating a rise in substance abuse incidents.
Los Angeles County, home to Sierra Madre, saw a 7% increase in opioid-related overdoses in 2021.
A 2019 survey showed that 12% of Sierra Madre high school students admitted to using marijuana in the past year.
In 2021, rehabilitation centers in Los Angeles County, where Sierra Madre is located, reported a 10% increase in admissions for methamphetamine addiction.
Sierra Madre Police Department documented a 3% rise in drug possession arrests in 2020 compared to the previous year.
A local survey in 2021 indicated 15% of residents acknowledged knowing someone affected by the opioid crisis in Sierra Madre.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Sierra Madre, CA, are becoming increasingly vigilant regarding drug use in the workplace. Many local businesses have implemented drug testing policies in compliance with California state laws and guidelines provided by the California Department of Industrial Relations. These policies aim to ensure a safe and productive work environment.
Regular drug screenings and random drug tests are part of the standard employment protocols in several sectors, especially those involving safety-sensitive roles. Employers recognize the importance of addressing drug use to reduce the risk of workplace accidents and maintain high standards of performance and conduct.
Moreover, Sierra Madre enterprises often offer employee assistance programs (EAPs) that provide support for workers struggling with addiction. These programs are supported by resources from the U.S. Department of Labor, promoting a healthy balance between work obligations and personal challenges.
The City of Sierra Madre, CA, has implemented several initiatives to tackle the drug problem. Local authorities collaborate with the Los Angeles County Department of Public Health to provide community-based resources and awareness campaigns. Educational programs are commonly held at local schools and community centers to inform residents about the dangers of drug abuse.
Additionally, the city partners with both state and federal agencies such as the Substance Abuse and Mental Health Services Administration (SAMHSA) to develop robust strategies aimed at reducing drug dependency and supporting addiction recovery services. These efforts are critical in maintaining public health and safety in Sierra Madre.
In recent months, Sierra Madre authorities have intensified their efforts to combat drug-related activities in the community. Several operations targeting distribution networks have led to significant arrests, disrupting supply chains in the region. This surge in enforcement reflects a coordinated effort among local law enforcement agencies to address the rise in illicit drug circulation.
The most notable event was a joint operation between the Sierra Madre Police Department and federal agencies, resulting in the seizure of a substantial quantity of narcotics. This operation was part of a broader initiative to dismantle organized crime groups involved in drug trafficking. The collaboration exemplifies the commitment to safeguarding the community from the adverse effects of drug abuse.
Community leaders in Sierra Madre have also played a crucial role in raising awareness and fostering dialogue around drug-related issues. Workshops and seminars have been organized to educate residents on the dangers of substance abuse and the importance of prevention. These efforts aim to empower individuals with the knowledge to make informed decisions and contribute to a safer environment.
Accredited Drug Testing offers fast, reliable employment screening services in Sierra Madre, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
County Alcohol & Drug Programs Administrators Association of California
City of Los Angeles Website
CA Behavioral Health Planning Council
Get Smart About Drugs
Shatterproof
California Health & Wellness
California Police Chiefs Association
California MAT Expansion Project
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024