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At our 38 testing locations in Upper San Gabriel Valley, California, Accredited Drug Testing offers a wide range of drug and alcohol screening services. These include both DOT and non-DOT tests such as urine drug tests, breath and EtG alcohol tests, and hair drug testing options suitable for personal, employment, or legal purposes. In Upper San Gabriel Valley, CA, we provide quick testing results with SAMSA certified laboratory analysis. Our services ensure that same day testing is usually available, and many centers are conveniently located close to you for easy access. Additionally, services like Occupational Health Testing, Clinical Testing, and Background Checks are offered.
To schedule a testing appointment, call (800) 221-4291 or register through our online platform. Just pick your desired test type and select a nearby location—testing can be arranged for personal use, employee screening, or testing another individual. With options to call our scheduling team or book online 24/7, setting up a test is both Fast and Easy. Our straightforward process lets you efficiently schedule drug testing sessions near Upper San Gabriel Valley with minimal hassle.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Upper San Gabriel Valley drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2022, Pasadena, Los Angeles County reported a 15% increase in drug-related hospital admissions.
Glendale, Los Angeles County saw a 10% rise in opioid overdoses from 2019 to 2023.
Arcadia, Los Angeles County reported a 25% increase in drug abuse cases among teenagers in 2021.
Monrovia, Los Angeles County has a drug-related crime rate that is 20% higher than the state average as of 2023.
In 2023, El Monte, Los Angeles County experienced a 12% decrease in drug abuse treatment admissions.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in the Upper San Gabriel Valley area often maintain strict drug testing policies to ensure workplace safety. Many companies adopt pre-employment screening, random testing, and post-accident tests. These policies align with federal guidelines outlined by the U.S. Department of Labor.
California's Drug-Free Workplace Program helps local businesses implement effective drug testing policies. Employers in the region, including cities like Arcadia and Monrovia, emphasize creating a supportive environment for employees who need help with substance abuse issues, ensuring compliance with EEOC regulations.
The government in Upper San Gabriel Valley is actively tackling drug abuse through various programs. Los Angeles County collaborates with local organizations to provide education and prevention initiatives. Efforts include the Drug-Free Communities Support Program, which aims to reduce youth substance use.
Partnerships with the CDC and SAMHSA enhance treatment options and resources. Police departments in cities like Pasadena and Glendale conduct regular drug take-back events to safely dispose of unused medications.
Recently, law enforcement agencies in the Upper San Gabriel Valley have intensified their efforts, leading to several significant drug busts. One notable incident involved a multi-agency operation that resulted in the seizure of large quantities of methamphetamine and fentanyl. This operation not only disrupted a major supply chain but also led to the arrest of key figures in the local drug distribution network.
In another event, a routine traffic stop by local police turned into a major drug bust. Officers discovered over 50 kilograms of cocaine hidden in a secret compartment of the suspect's vehicle. This discovery has resulted in a broader investigation into cross-border drug trafficking activities linked to the vehicle.
Additionally, a recent raid on a clandestine drug lab in the valley uncovered an illicit production facility for synthetic drugs. This operation highlighted the growing sophistication of drug manufacturing methods employed by criminal organizations, prompting authorities to adopt more advanced investigative techniques.
Accredited Drug Testing offers fast, reliable employment screening services in Upper San Gabriel Valley, CA. Trusted by employers nationwide for accurate results and exceptional service.
California DOT/Non DOT Physicals
Sacramento County Drug and Alcohol Services
Los Angeles County Substance Abuse Prevention and Control
Partnership to End Addiction
California Department of Public Health - o-drug Program
Heal Community Action Network
California Consortium of Addiction Programs and Professionals
HealthRIGHT 360
PHFE WIC Resource Directory
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024