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Accredited Drug Testing delivers extensive drug and alcohol testing services across 34 centers in the Marshfield Center, Massachusetts vicinity. Our portfolio encompasses DOT and non-DOT urine drug screenings, breath and EtG alcohol tests, as well as hair drug analyses, tailored for individual, employer, and legal purposes. Rapid testing services and SAMSA-certified lab analyses are readily available, ensuring prompt results in Marshfield Center, MA. Many testing locations are conveniently close to where you reside or work. We also provide additional services like Occupational Health Evaluations, Clinical Diagnostics, and Background Verification.
Dial (800) 221-4291 or visit our website to register. Choose a test, pick a nearby venue—our services extend to personal, workforce, or third-party testing. Scheduling is straightforward and without hassle. Contact our scheduling team or book your test online anytime. With our efficient and intuitive system, organizing a drug test near Marshfield Center is a breeze.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Marshfield Center drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In 2021, Plymouth County, where Marshfield Center is located, reported an opioid-related overdose death rate of 21.4 per 100,000 residents.
The Massachusetts Department of Public Health reported 54 opioid-related deaths in Plymouth County during the first six months of 2022.
A 2020 study showed that Marshfield Center, part of Plymouth County, experienced a 15% increase in opioid prescriptions over a five-year period.
In 2022, Marshfield Center saw an increase in local law enforcement drug arrests by 8% compared to 2021.
Local health officials in Marshfield Center reported a significant rise in emergency room visits due to substance abuse in 2021.
Plymouth County's substance abuse service rate is supported by numerous programs, with Marshfield Center contributing significantly to community outreach.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Marshfield Center, MA are increasingly proactive about addressing substance abuse in the workplace. Many have adopted policies that promote drug-free environments as part of their efforts to ensure safety and productivity. These policies often include pre-employment drug testing and random screening.
Companies often partner with agencies such as the Substance Abuse and Mental Health Services Administration to provide employees with access to educational resources and support networks. Both public and private sector employers in the area stress the importance of a supportive approach, balancing disciplinary measures with access to recovery programs.
In addition to testing policies, workplace initiatives in Marshfield Center frequently include wellness programs that offer advice on mental health care alongside substance abuse support. These initiatives are crucial for fostering a positive work environment where employees feel valued and supported.
In response to the rising drug problems, Marshfield Center in Plymouth County has initiated numerous government efforts. The local government collaborates with the Massachusetts Executive Office of Health and Human Services to implement substance abuse prevention programs and improve access to treatment services. They have also partnered with regional coalitions to enhance community awareness.
The state's investment in healthcare providers across the region aims to improve outcomes for residents battling addiction. A focus on data-driven approaches is just one aspect of this broader initiative. In Marshfield Center, these efforts are complemented by support from the Bureau of Substance Addiction Services, which provides guidance and resources.
Recent years have seen Marshfield Center become the focus of several major drug-related events. Local law enforcement in Plymouth County has worked diligently, successfully executing multiple drug busts in collaboration with the regional task force.
In mid-2022, a coordinated operation led to the seizure of significant quantities of heroin and fentanyl, highlighting the ongoing battle against opioid distribution in the area. This and other operations are part of a broader initiative focused on disrupting drug trafficking networks affecting Marshfield Center and beyond.
Community engagement events are also prevalent, aiming to educate residents on the dangers of drug abuse and to promote available support systems. Such events often involve collaboration with local organizations and health agencies aimed at reducing stigma and encouraging individuals to seek help.
Accredited Drug Testing offers fast, reliable employment screening services in Marshfield Center, MA. Trusted by employers nationwide for accurate results and exceptional service.
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Reach Massachusetts
MA Substance Use Helpline
Plymouth County Public Health
Bureau of Substance Addiction Services
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024