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At our 31 locations in North Marshfield, MA, Accredited Drug Testing delivers extensive screening services for drugs and alcohol. We accommodate both DOT and non-DOT urine drug analysis, breath alcohol screenings, EtG alcohol evaluations, and hair analyses catering to personal, workplace, and legal requirements. Our swift testing results and SAMSA endorsed lab assessments are readily available, and most centers are conveniently located near your residence or office in North Marshfield. Our additional offerings consist of Occupational Health Testing, Clinical Testing, and Background Checks.
Dial (800) 221-4291 or sign up online to schedule your test. Select your test type and the closest facility for personal, employee, or third-party testing. With a hassle-free and straightforward process, booking a test is speedy and straightforward—contact our scheduling team or arrange your test online anytime. Our service ensures easy, efficient drug testing scheduling in the North Marshfield area.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our North Marshfield drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
North Marshfield, located in Plymouth County, has experienced a notable increase in opioid-related deaths by 15% over the past year.
In a recent survey, 10% of North Marshfield residents in Plymouth County admitted to recreational drug use.
Plymouth County reported a 25% surge in heroin-related arrests, with a significant portion occurring in North Marshfield.
North Marshfield hospitals noted a 20% increase in emergency room visits related to drug overdoses over the last year.
Plymouth County recorded that 30% of drug-related crime in the area was linked to prescription drug misuse, affecting North Marshfield too.
Recovery programs saw a 12% enrollment uptick in North Marshfield, according to Plymouth County's latest report.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in North Marshfield, MA, are adopting stringent drug testing policies to combat workplace substance abuse. Many employers adhere to state guidelines set by the Massachusetts Department of Industrial Accidents to promote a drug-free environment.
Local companies emphasize pre-employment and random drug testing, ensuring compliance with federal regulations. These measures, supported by widespread employee assistance programs, aim to maintain workplace safety and productivity.
Additionally, North Marshfield businesses work closely with organizations such as the Substance Abuse and Mental Health Services Administration (SAMHSA), providing resources for employees struggling with addiction.
The government has been actively addressing drug problems in North Marshfield, MA, through increased funding for prevention and recovery programs. Collaborations with state agencies like the Executive Office of Health and Human Services aim to reduce addiction rates and support affected families.
Local initiatives by Plymouth County have implemented drug education in schools and community outreach programs. These efforts, supported by the county's partnership with the Massachusetts Department of Public Health, focus on awareness and early intervention to prevent substance abuse.
North Marshfield has witnessed several significant drug busts aimed at curbing illicit drug activity. Recently, Plymouth County law enforcement conducted a major operation resulting in the seizure of large quantities of heroin, showcasing their commitment to tackling local drug issues.
Community events focused on drug awareness and prevention are regularly held, engaging residents in educational programs. These events aim to inform the public about the dangers of drug abuse and the resources available for those seeking help.
The town has also partnered with local organizations to host annual 'Drug-Free' campaigns, highlighting success stories of recovery and the importance of a supportive community in fighting addiction.
Accredited Drug Testing offers fast, reliable employment screening services in North Marshfield, MA. Trusted by employers nationwide for accurate results and exceptional service.
Massachusetts DOT/Non DOT Physicals
Massachusetts Substance Use Helpline
Baystate Health - Substance Use and Addiction
MCPHS - Substance Abuse Resources
Lahey Health - Addiction Treatment Services
Southcoast Health - Addiction Services
Boston Recovery Services
Hub Center for Health - Substance Abuse Center
Center of Excellence and Addiction Faculty
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024