Our automated scheduling system is available 24/7. Order your test online and receive your donor/registration pass by email. Click Here
Same Day Service
Accredited Drug Testing provides a full array of drug and alcohol testing services at 40 convenient centers around State Line, Pennsylvania. Our services range from DOT and non-DOT urine drug tests to breath alcohol exams, EtG alcohol screens, and hair drug assessments for personal, workplace, and legal purposes. In the State Line area, we offer quick testing with SAMSA-certified lab analysis. Same-day service is an option, with centers located conveniently near your home or office. We also provide Occupational Health Screening, Clinical Assessments, and Background Verification.
Dial (800) 221-4291 or book online. Just pick the test you need and select a nearby site—suitable for personal use or for employees. Setting up a test is quick and straightforward; contact our scheduling team or book your appointment online at any time. Our efficient, accessible process allows simple arrangement of drug testing in State Line.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our State Line drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Franklin County reported a 20% increase in drug-related arrests in State Line, PA, over the past year.
In 2022, State Line, located in Franklin County, had a 15% rise in opioid overdose cases.
State Line's Franklin County experienced a 30% increase in naloxone administrations by first responders.
Substance abuse treatment programs in State Line, Franklin County saw a 25% enrollment increase in 2022.
In Franklin County, State Line accounted for 10% of the county's drug-related hospitalizations.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in State Line, PA, are prioritizing drug-free workplaces to ensure safety and productivity. Many businesses adopt drug testing policies as part of their employment requirements. They often collaborate with the Substance Abuse and Mental Health Services Administration to structure effective programs.
Drug screenings may be conducted pre-employment, randomly, or post-incident to maintain a safe working environment. State Line's proximity to major transport routes necessitates stringent adherence to federal and state guidelines regarding drug use and testing.
State Line, PA, in Franklin County, has seen the implementation of several government initiatives to combat drug issues. The Pennsylvania Commission on Crime and Delinquency supports local law enforcement's efforts to reduce drug trafficking.
Furthermore, the Pennsylvania Department of Drug and Alcohol Programs collaborates with county agencies to fund rehabilitation programs and awareness campaigns to help combat addiction in communities like State Line. Their initiatives aim to provide holistic support and reduce drug dependency risks.
Recent operations in State Line, PA, have led to significant drug busts, disrupting local drug networks. These incursions are the result of coordinated efforts between local and state law enforcement agencies, targeting illegal operations in Franklin County.
Community events focusing on drug awareness and prevention have been organized, providing residents with resources and education about the dangers of substance abuse. Such initiatives are crucial in fostering community resilience against drug-related activities.
Accredited Drug Testing offers fast, reliable employment screening services in State Line, PA. Trusted by employers nationwide for accurate results and exceptional service.
Pennsylvania DOT/Non DOT Physicals
Department of Drug and Alcohol Programs
Allegheny County Health Department
Commonwealth of Pennsylvania
HealthPA.gov
PA Certification Board
SAMHSA Helpline
Get n-drug Now
Overdose Lifeline
Quickly find trusted local drug testing centers in State Line, PA — fast, convenient, and reliable every time!
Quickly find a local DOT drug testing center in State Line, PA — fast, reliable, convenient nationwide service!
DNA testing for legal and non-legal purposes including child support, and child custody around State Line, PA.
Including specimen collector training, DER training, reasonable suspicion training and much more in State Line, PA.v
Get fast, accurate hair drug testing at our convenient State Line, PA locations—results you can trust, every time!
Fast, reliable alcohol testing to keep your workplace safe and compliant every single day in State Line, PA.
Reliable nationwide drug testing services ensuring accuracy, compliance, and quick results for businesses and individuals in State Line, PA.
Accurate 5 panel drug testing with fast, confidential results—trusted by State Line, PA employers and individuals nationwide.
Comprehensive 10 panel drug testing with fast, reliable results—trusted for State Line, PA workplace and personal testing needs.
Convenient on-site mobile drug testing with fast, reliable results—saving time while keeping your State Line, PA workplace compliant.
Certified DOT physicals with quick, reliable exams to keep State Line, PA drivers compliant and on the road with confidence.
Join our DOT consortium for hassle-free compliance, random testing management, and reliable driver safety solutions.
This is by far the easiest way to get my lab work ordered and paid for. The phone calls are short and to the point. They don’t try to push extra sales on you and when I walk in to the clinic I simply show my donor pass and with in a matter of minutes I’m done. I will continue to use ADT in the future.
Jason Jackson - 7/19/2025
Everything was great, the staff was very polite. Thank you.
Olga Petrova - 9/19/2024
The visit here is always the best . The place is always really clean. The employees are super courteous, very polite, and professional. This is the only drug lab I like to go do my drug and alcohol test. I would like to tell them thank you so much for thier excellent performance and job
Eli Gonzalez - 1/4/2025