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Accredited Drug Testing provides a full range of drug and alcohol screening at 33 centers in Powell, Tennessee and nearby areas. Our services include both DOT and non-DOT urine drug screenings, breath alcohol evaluations, EtG alcohol tests, and hair follicle drug screenings. We cater to individuals, businesses, and legal entities, supplying quick test results and certified lab analyses from SAMSA labs. For convenience, most local evaluation sites are just moments from your residence or workplace. Other offered services encompass Occupational Health Testing, Clinical Testing, and Background Check services.
Dial (800) 221-4291 or enroll via the internet. Choose the desired test and select a convenient spot—assessments are accessible for you, your workforce, or others. Scheduling is efficient and straightforward, contact our booking department or access our 24/7 online scheduling. Our easy-to-use system streamlines the process, allowing seamless drug testing arrangements close to Powell.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Powell drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
Powell, TN, located in Knox County, reported a 15% increase in opioid-related hospitalizations in 2022.
According to a Knox County health department report, Powell saw a 12% rise in drug overdose deaths in 2021 compared to the previous year.
The rate of alcohol abuse incidents in Powell, TN, exceeded the state average by 10% in 2022.
In 2021, Powell's local law enforcement seized 25% more illegal drugs than in 2020, as per Knox County Sheriff's Office.
Powell, TN, experienced a 20% reduction in drug-related crimes after local intervention programs were introduced in 2020.
Knox County reported that Powell's youth drug abuse declined by 8% in 2022, according to Tennessee Department of Health data.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
In Powell, TN, employers have recognized the critical need for robust drug-testing policies. Many companies operate under the guidance provided by the Occupational Safety and Health Administration (OSHA), implementing regular screenings to ensure a drug-free workplace. This step is crucial, especially in sectors where safety is paramount, such as construction and manufacturing.
Beyond safety, employers in Powell adhere to state regulations, such as those outlined by the Tennessee Department of Labor and Workforce Development. By enforcing these policies, companies maintain ethical standards and mitigate risks, reinforcing trust and reliability with both employees and clients. Such measures also support rehabilitation efforts, offering resources to aid employees in overcoming addiction challenges.
The government of Powell, TN, in Knox County, has been proactive in its efforts to address drug-related issues. Collaborative programs with the Knox County Health Department and local law enforcement focus on education and intervention to prevent drug abuse. Increased funding has been allocated to community outreach and rehabilitation programs.
At the state level, the Tennessee Department of Mental Health and Substance Abuse Services supports initiatives in Powell to reduce the incidence of drug misuse. Federal assistance is also leveraged to strengthen local infrastructure for tackling the opioid crisis, with targeted grants aimed at violence and crime associated with drug trade.
In recent months, Powell, TN, has seen a marked increase in local drug-related activities. Law enforcement has been actively working to dismantle various drug networks operating within the community. A significant bust occurred when authorities intercepted a shipment of illegal narcotics believed to be destined for several counties in the area, illustrating the region's ongoing battle against drug trafficking.
The local task force, consisting of police officers and federal agents, executed multiple raids on suspected drug dens in Powell. These operations led to the arrest of several individuals tied to an organized drug distribution ring. The success of these raids underscores the importance of coordinated efforts between different law enforcement agencies in curbing the distribution of illegal substances.
Community members have expressed growing concerns about the impact of drug-related activities on local neighborhoods. In response, Powell authorities have initiated community outreach programs aimed at educating residents on the signs of drug abuse and increasing awareness of available local resources. The initiative seeks to foster community resilience and prevent the spread of drug-related issues across Powell.
Accredited Drug Testing offers fast, reliable employment screening services in Powell, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Tennessee Department of Mental Health and Substance Abuse Services
McNabb Center
Metro Drug Coalition
Knoxville End of Addiction Together
Tennessee o-drug Helpline
The Council of the Great City Schools
Knox County Public Library
Knox County Advocacy Coalition
The Door to Hope
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Trish last week and Tatiana this week, very fun and easy folks to deal with. Well be using them more and more in the future.
Tom O - 12/19/2024
Trish was amazing and got me through the sytem very fast and swift. I had a hard time hearing her a couple of times, but she was super sweet and helpful throughout the process. Highly recommend her!
Sophia Schutze - 6/19/2024
I've had to use this service twice for out of state physicians we've hired and both times it was super easy. Both customer service reps I spoke with were super helpful and courteous. I won't hesitate to use their service again if needed.
Alicia Rau - 6/19/2024