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Accredited Drug Testing delivers thorough drug and alcohol screening solutions through 35 local testing sites in the Makaha, Hawaii region. Our services include DOT, non-DOT urine tests, breathalyzer tests, EtG alcohol analysis, and hair drug examinations tailored for personal, occupational, or judicial purposes. In the Makaha, HI vicinity, we offer rapid results and SAMSA-approved lab evaluations with same-day service, conveniently located near your residence or workplace. Additional offerings encompass Occupational Health Evaluations, Clinical Examinations, and Background Verifications.
Dial (800) 221-4291 or sign up online. Select your required test and pick a nearby center—services can be arranged for yourself, workforce, or other individuals. Booking an appointment is quick and simple through our scheduling team, or arrange your test digitally at any time. Our efficient and intuitive system makes organizing drug testing near Makaha straightforward.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Makaha drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Makaha, HI, part of Honolulu County, the opioid prescription rate was noted at 48.3 per 100 individuals in 2019.
Reported methamphetamine use among teens in Makaha, HI, Honolulu County, was reported at 6% in 2020.
In Honolulu County, including Makaha, HI, approximately 14% of DUI arrests involved drug impairment in 2019.
From 2018 to 2019, drug-related overdose deaths increased by 9% in Honolulu County, impacting areas like Makaha, HI.
Makaha, HI, within Honolulu County, accounted for about 50 cases of drug possession arrests in 2020.
The rate of drug-related emergency room visits in Honolulu County, encompassing Makaha, HI, was noted to be 258 per 100,000 in 2019.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Makaha, HI, assert drug-free workplace policies due to local regulations and state guidelines. To combat drug issues, companies often establish strict testing measures, particularly for safety-sensitive positions. The Hawaii Department of Labor and Industrial Relations provides resources for implementing effective drug-testing policies.
These measures are crucial in maintaining a safe work environment, reducing potential liabilities, and enhancing workplace productivity. Employers may implement pre-employment screening, random testing, and reasonable suspicion testing to enforce their policies.
The government of Hawaii, addressing the drug issues in areas like Makaha in Honolulu County, has invested in several initiatives. Programs such as the Hawaii DOH Substance Abuse Services focus on prevention and treatment strategies for drug misuse.
Moreover, collaborations with federal agencies, including the Hawaii High Intensity Drug Trafficking Area (HIDTA), aim to curb drug trafficking and distribution. Community outreach programs have also been enhanced to raise awareness and encourage community participation.
In recent months, Makaha, HI has witnessed a significant increase in drug-related activities, leading to multiple police interventions. Local law enforcement agencies have ramped up efforts to control the inflow of illegal substances, focusing primarily on high trafficking zones. Operations often target known hotspots where drug transactions occur frequently.
A prominent bust led to the arrest of several individuals involved in an organized drug distribution ring. This operation was the result of a months-long investigation that included undercover work and surveillance. The crackdown aimed to dismantle networks associated with methamphetamine distribution, a persistent issue plaguing the community.
Community involvement has been key in tackling these drug challenges. Residents have participated in neighborhood watch programs and collaboratives with law enforcement to report suspicious activities. These partnerships have yielded positive outcomes, including significant reductions in drug-related crimes in targeted areas.
Public awareness campaigns have been instrumental in educating the local population about the dangers of drug abuse. Workshops and seminars are frequently held to inform the community, particularly the youth, about the repercussions of drug use and how to seek help. Local schools are also involved, incorporating drug education into their curriculum.
Accredited Drug Testing offers fast, reliable employment screening services in Makaha, HI. Trusted by employers nationwide for accurate results and exceptional service.
Hawaii Department of Health Substance Abuse Services
Hawaii High Intensity Drug Trafficking Area
Action with Aloha, Inc.
Hope Services Hawaii
Hawaii Counseling and Mediation Center
Substance Abuse and Mental Health Services Administration
Mental Health America of Hawaii
Laulima Health Services
Helping Hands Healthcare
Hawaii Parents and Children Together
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Time was running out before my Cdl got downgraded because of a violation I had on clearinghouse. I couldn't find an employer to send me for my return to duty test, but these guys had my test scheduled and done in the same day! They saved my cdl. Thank you again!
Michael Williams - 12/2/2024
I always have a good experience setting up company driver drug screens through ADT. I'm really happy I found them while searching online, they have made my job much easier.
Exodus Heath - 2/13/2025
I use their service for new hire and DOT employee's. Spoke with Taisha Walker this morning, and she was very helpful. She made the process smooth and seamless.
Christina Galdos - 3/9/2025