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Accredited Drug Testing offers a diverse range of drug and alcohol screening services at our 33 centers throughout Memphis, Tennessee. We conduct DOT and non-DOT urine tests, breath alcohol screenings, EtG tests, and hair follicle drug analyses for private, professional, and legal purposes. We ensure swift results with both rapid testing and SAMSA-certified lab evaluations; same-day service is accessible, and most testing sites around Memphis are conveniently located close to your home or workplace. Furthermore, we offer Occupational Health Testing, Clinical Testing, and Background Checks.
Give us a call at (800) 221-4291 or go online to sign up. Choose your preferred test and the nearest location—testing can be scheduled for yourself, your employees, or others. With our 24/7 online scheduling or dedicated phone line, setting up a test is quick and simple. Our efficient and intuitive system makes arranging local drug testing near Memphis straightforward.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Memphis drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
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If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
As of 2022, Shelby County reported an opioid overdose death rate of approximately 30 per 100,000 residents, highlighting a concerning trend in Memphis, TN.
In 2021, Memphis, TN, saw over 2,000 reported arrests related to drug possession, reflecting persistent drug abuse issues in Shelby County.
Approximately 8% of high school students in Memphis, TN, admitted to using illicit drugs, according to a 2020 survey conducted within Shelby County.
Shelby County's emergency departments treated over 1,500 cases related to drug overdoses in 2021, showcasing the widespread impact of drug abuse in Memphis, TN.
Methamphetamine-related incidents in Memphis, TN, accounted for nearly 15% of drug-related crimes in Shelby County as of 2021.
In 2020, Shelby County noted an increase in drug-related hospitalizations by 12%, underscoring the drug problem in Memphis, TN.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Employers in Memphis, TN, implement drug testing to maintain safety and productivity. Testing may occur pre-employment and randomly, guided by policies compliant with OSHA standards. Local businesses prioritize a drug-free workplace to ensure legal compliance and employee well-being.
Small businesses in Shelby County seek drug testing solutions through providers like Shelby County Government's resources. These policies reduce liability and improve competitiveness in the job market by maintaining a safe work environment.
Government efforts to combat drug issues in Memphis, TN, are spearheaded by the Shelby County Drug Court and the Tennessee Department of Mental Health and Substance Abuse Services. These initiatives provide oversight and programs for rehabilitating offenders.
Memphis Police Department partners with federal agencies for drug bust operations, significantly reducing availability. Additionally, state initiatives like the Tennessee Together plan aim to curb opioid abuse through legislation and treatment programs.
Local drug busts in Memphis, TN, often make headlines, with law enforcement seizing significant quantities of drugs. In a notable recent event, authorities intercepted a shipment containing heroin destined for Shelby County, demonstrating robust law enforcement vigilance.
A collaborative operation in 2023 between federal agents and Memphis police led to the arrest of several key figures in a drug trafficking ring, disrupting a major supply chain. These events highlight ongoing efforts to combat illegal drug operations.
Accredited Drug Testing offers fast, reliable employment screening services in Memphis, TN. Trusted by employers nationwide for accurate results and exceptional service.
Tennessee DOT/Non DOT Physicals
Memphis Recovery Centers
Community Against Substance Abuse
Cumberland Heights
UT Behavioral Health Center
Mental Health Resources
Alliance Healthcare Services
Wellstone Behavioral Health
Tennessee Department of Mental Health
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Quick, knowledgeable and courteous Janelle worked diligently to support me. I am recommending their services to anyone looking.
Greensboro Joseph - 11/19/2024
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